Sr. Director, Evidence Generation

Role Summary

Sr. Director, Evidence Generation leads comparative effectiveness research and health outcomes initiatives within Medical Affairs to inform clinical decision-making, demonstrate therapy value, and advance patient outcomes. The role designs and executes evidence generation programs across the product lifecycle, with a focus on real-world data, pragmatic study designs, and advanced analytics to optimize evidence strategies. You will work with cross-functional teams to ensure evidence plans support product value and access.

Responsibilities

• Lead and design comparative effectiveness and health outcomes studies using real-world data (RWD), registries, claims databases, and clinical data sources
• Develop strategic evidence plans addressing clinical, payer, and patient stakeholder needs
• Apply advanced study designs (e.g., propensity score matching, instrumental variables, target trial emulation) to generate credible, high-impact insights
• Focus on CER, health outcomes innovation, and advanced analytics to optimize evidence strategies across the product lifecycle
• Collaborate cross-functionally with Clinical Development, HEOR, Market Access, and Data Science teams to align evidence strategies with organizational priorities
• Communicate findings in scientific forums, peer-reviewed publications, and internal stakeholder briefings
• Serve as a subject matter expert in comparative effectiveness research within Medical Affairs
• Represent the company in external collaborations, advisory boards, and industry working groups focused on RWE and methodological innovation
• Provide mentorship and scientific guidance to evidence scientists and cross-functional partners

Education

• Advanced degree (PhD, PharmD, MD, MPH, or MS) in Epidemiology, Health Economics, Biostatistics, Data Science, or related field

Qualifications

• Required: 5–10+ years of experience in evidence generation, comparative effectiveness, or HEOR in a pharmaceutical, biotech, or academic setting
• Required: Demonstrated expertise in designing and executing real-world data studies and comparative analyses
• Required: Strong track record of scientific publications and presentations
• Preferred: Experience in comparative effectiveness and statistical methodology
• Preferred: Ability to bridge technical analytical methods and clinical impact narratives

Skills

• Excellent communication, stakeholder management, and strategic thinking
• Cross-functional collaboration and mentorship
• Ability to translate complex analyses into actionable insights

Additional Requirements

• Travel: This is a U.S.-based remote role with quarterly, or as-needed visits to San Francisco, CA