Sr. Director, Clinical Science (Oncology)
Xencor
July 01, 2026
Remote friendly (San Diego, CA)
United States
$247,700 - $309,000 USD yearly
Clinical Research and Development
Summary:
Responsible for facilitating successful and timely initiation and completion of clinical development programs by executing and monitoring medical aspects of selected clinical trials.
Primary Responsibilities:
- Create clinical trial documents, including clinical protocols, investigator brochures, DSURs, and IND clinical modules (with Study Medical Directors).
- Work with Clinical Operations to execute trials with high quality and on agreed timelines.
- Perform ongoing review of clinical data, including query generation/resolution and data analysis; review draft listings to support data cleaning and interpretation.
- Provide scientific expertise to Clinical Operations by responding to questions and clarifying issues during study conduct.
- Provide internal safety monitoring in collaboration with the Study Medical Director.
- Provide medical input to clinical database build, CRFs, monitoring plan, data management plan, safety monitoring plan, and statistical analysis plan.
- Develop and maintain relationships with investigators and therapeutic area key opinion leaders.
- Lead review of study data and develop CSRs, clinical presentations, and publications.
- Support Clinical Development and Regulatory Affairs as required; participate on multidiscipline project teams.
- Ensure adherence to department/company policies; provide oversight and direction to direct/indirect reports.
Education/Experience/Skills (Qualifications):
- BS in life sciences required; PhD, RN, PharmD, or MS preferred.
- 15+ years relevant pharmaceutical industry experience in clinical development; 4+ years focused in assigned therapeutic area.
- Clinical scientist experience in data review, safety monitoring, protocol development, data analyses/interpretation, and publications; cross-functional clinical trial team experience and investigator liaison.
- Preferred: translational medicine/early phase trials, monoclonal antibody biologics/immunotherapy; experience across full study lifecycle to database lock and CSR.
Required/Preferred Skills:
- Strong initiative, organization, hands-on approach, attention to detail.
- Expertise analyzing/interpreting emerging clinical data; software skills (e.g., pivot tables, EDC, MS Office/Visio, GraphPad Prism, Spotfire, Medidata RAVE, Inform).
- Ability to prioritize multiple tasks independently; excellent communication; adapt communication to audience.
- Leadership/management via coaching and supervision.
Benefits/Compensation (explicitly stated):
- Competitive total rewards including 401k match, healthcare coverage, ESPP; eligible for annual bonus and equity grant.
Application Instructions:
- For more information, see https://xencor.com/careers/.
Responsible for facilitating successful and timely initiation and completion of clinical development programs by executing and monitoring medical aspects of selected clinical trials.
Primary Responsibilities:
- Create clinical trial documents, including clinical protocols, investigator brochures, DSURs, and IND clinical modules (with Study Medical Directors).
- Work with Clinical Operations to execute trials with high quality and on agreed timelines.
- Perform ongoing review of clinical data, including query generation/resolution and data analysis; review draft listings to support data cleaning and interpretation.
- Provide scientific expertise to Clinical Operations by responding to questions and clarifying issues during study conduct.
- Provide internal safety monitoring in collaboration with the Study Medical Director.
- Provide medical input to clinical database build, CRFs, monitoring plan, data management plan, safety monitoring plan, and statistical analysis plan.
- Develop and maintain relationships with investigators and therapeutic area key opinion leaders.
- Lead review of study data and develop CSRs, clinical presentations, and publications.
- Support Clinical Development and Regulatory Affairs as required; participate on multidiscipline project teams.
- Ensure adherence to department/company policies; provide oversight and direction to direct/indirect reports.
Education/Experience/Skills (Qualifications):
- BS in life sciences required; PhD, RN, PharmD, or MS preferred.
- 15+ years relevant pharmaceutical industry experience in clinical development; 4+ years focused in assigned therapeutic area.
- Clinical scientist experience in data review, safety monitoring, protocol development, data analyses/interpretation, and publications; cross-functional clinical trial team experience and investigator liaison.
- Preferred: translational medicine/early phase trials, monoclonal antibody biologics/immunotherapy; experience across full study lifecycle to database lock and CSR.
Required/Preferred Skills:
- Strong initiative, organization, hands-on approach, attention to detail.
- Expertise analyzing/interpreting emerging clinical data; software skills (e.g., pivot tables, EDC, MS Office/Visio, GraphPad Prism, Spotfire, Medidata RAVE, Inform).
- Ability to prioritize multiple tasks independently; excellent communication; adapt communication to audience.
- Leadership/management via coaching and supervision.
Benefits/Compensation (explicitly stated):
- Competitive total rewards including 401k match, healthcare coverage, ESPP; eligible for annual bonus and equity grant.
Application Instructions:
- For more information, see https://xencor.com/careers/.