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Sr. Director, Clinical Research-CVM Nephrology

Alnylam Pharmaceuticals
September 04, 2026
Full-time
Remote friendly (Cambridge, MA)
Worldwide
Clinical Research and Development
Role: Senior Medical Director, Clinical Research in CVM therapeutic area, leading early-stage kidney programs with a focus on RNAi therapeutics. Objectives include driving clinical strategy, advancing first-in-human and proof-of-concept studies, and ensuring operational excellence. Responsibilities encompass clinical program leadership, trial oversight, safety monitoring, development of clinical development plans (CDPs), cross-functional collaboration with R&D, Regulatory, and Medical Affairs, and external scientific engagement. Qualifications: MD or MD/PhD, Board Certified or specialist training in Nephrology preferred; 5+ years industry experience in early-phase CVM or renal drug development, including trial design, regulatory interactions, and program leadership. Skills include strategic planning, scientific judgment, medical monitoring, and navigating internal governance. High-Value: focus on RNAi therapeutics in kidney disease, early clinical development, first-in-human trials, extensive cross-functional and external collaboration. Work setup: hybrid at Cambridge, MA; travel not specified.