Sr. Biostatistician II
Vertex Pharmaceuticals
August 18, 2026
Remote friendly (Boston, MA)
United States
Clinical Research and Development
General Summary
- The Senior Biostatistician II performs scientific statistical analyses supporting Global Medicines Development and Affairs with guidance/mentoring on new and complex issues, developing drug-development biostatistics expertise.
Key Duties and Responsibilities
- Design, develop, and execute statistical infrastructure for clinical trials, observational studies, or real-world data (RWD).
- Represent Biostatistics in Study Execution Team (SET) meetings.
- Author study Statistical Analysis Plans (SAPs), including TFL shells, and support presentation to Statistical Review Forum (SRF).
- Plan and conduct cross-functional data reviews (xFDR), Key Results Memos (KRM), and Data Dissemination Plans (DDP).
- Collaborate with statistical programming to deliver high-quality TFLs; provide input into programming specifications and review.
- Develop protocol statistical sections (sample size estimates, randomization plan).
- Contribute to CSRs; may author/co-author publications and posters.
- Implement study-level design/analysis methods; participate in SRF discussions.
- Contribute to technical/operational departmental working groups; seek mentoring when needed.
Knowledge, Skills, and Qualifications
- SAS and R proficiency.
- Strong understanding of statistical methods used in drug development.
- Critical thinking/logical problem-solving.
- Excellent written and verbal communication; teamwork and collaboration with non-statisticians.
- PhD or MS in Statistics/Biostatistics; typically 3 years’ experience for MS (or equivalent).
Compensation/Benefits and Flex
- Pay range: $132,200–$198,200; eligible for annual bonus and annual equity awards (and possibly overtime).
- Hybrid/On-site flexibility: hybrid (remote up to 2 days/week) or on-site (5 days/week, ad hoc flexibility).
- The Senior Biostatistician II performs scientific statistical analyses supporting Global Medicines Development and Affairs with guidance/mentoring on new and complex issues, developing drug-development biostatistics expertise.
Key Duties and Responsibilities
- Design, develop, and execute statistical infrastructure for clinical trials, observational studies, or real-world data (RWD).
- Represent Biostatistics in Study Execution Team (SET) meetings.
- Author study Statistical Analysis Plans (SAPs), including TFL shells, and support presentation to Statistical Review Forum (SRF).
- Plan and conduct cross-functional data reviews (xFDR), Key Results Memos (KRM), and Data Dissemination Plans (DDP).
- Collaborate with statistical programming to deliver high-quality TFLs; provide input into programming specifications and review.
- Develop protocol statistical sections (sample size estimates, randomization plan).
- Contribute to CSRs; may author/co-author publications and posters.
- Implement study-level design/analysis methods; participate in SRF discussions.
- Contribute to technical/operational departmental working groups; seek mentoring when needed.
Knowledge, Skills, and Qualifications
- SAS and R proficiency.
- Strong understanding of statistical methods used in drug development.
- Critical thinking/logical problem-solving.
- Excellent written and verbal communication; teamwork and collaboration with non-statisticians.
- PhD or MS in Statistics/Biostatistics; typically 3 years’ experience for MS (or equivalent).
Compensation/Benefits and Flex
- Pay range: $132,200–$198,200; eligible for annual bonus and annual equity awards (and possibly overtime).
- Hybrid/On-site flexibility: hybrid (remote up to 2 days/week) or on-site (5 days/week, ad hoc flexibility).