Sr Associate Scientist, Metabolic & Muscle Diseases

As a Sr Associate Scientist, you will serve as a central histological resource providing expert tissue processing and staining services across multiple research programs.

Responsibilities:
- Manage end-to-end histological workflows for multiple tissue types (e.g., liver, heart, brain, muscle, adipose), including fixation, dehydration, clearing, embedding, and sectioning.
- Perform routine and special histological staining (e.g., H&E, Sirius Red, PAS, Oil Red O).
- Conduct IHC and IF; develop, optimize, and validate IHC/IF protocols, antibody titrations, and antigen retrieval conditions.
- Apply ISH techniques (e.g., RNAscope) for gene expression localization.
- Acquire whole-slide images using platforms such as Aperio and Zeiss Axioscan; manage image data repositories.
- Perform quantitative image analysis using tools such as HALO and develop customized analysis algorithms.
- Create high-quality figures and data summaries for reports, regulatory packages, and publications.
- Maintain and communicate a workload tracker; flag capacity/scheduling conflicts; adapt to shifting priorities and animal study schedules.
- Maintain accurate and complete laboratory records.

Qualifications/Skills:
- BS with 5+ years or MS with 2+ years relevant experience.
- Proficiency in standard and special histochemical staining across multiple tissue types.
- Demonstrated IHC/IF assay development, optimization, and troubleshooting.
- Ability to optimize protocols for challenging tissues/low-abundance samples.
- Experience with whole-slide imaging and digital pathology software (e.g., HALO).
- In situ hybridization experience (RNAscope, BaseScope, FISH) is a plus.
- Strong organizational/record-keeping skills; can manage multiple stakeholder requests.
- Excellent oral and written communication; ability to present data at lab meetings.

Application:
- Apply now.