Spring 2026 Co-op: In-Process Analytics

Role Summary

Spring 2026 co-op on the Chemistry team focusing on in-process analytics and purification of large RNA molecules (gRNA). The candidate will participate in routine laboratory activities including recording and taking UV absorbance measurements with NanoDrop, supporting purification, analyzing samples by UPLC and mass spectrometry, and endotoxin testing of synthetic guide RNA. The role involves learning various in-process analytical techniques, gaining proficiency in oligonucleotide characterization, supporting data generation and documentation, and presenting results at weekly team meetings.

Responsibilities

• Support characterization and purification of Prime’s long guide RNA (gRNA) using various laboratory techniques (e.g., ÄKTA purifier, UPLC, LC-MS, NanoDrop, endotoxin assays)
• Integrate chromatograms for gRNA crude, fraction, and final samples using Prime’s SOPs to quantify full-length product purity and tabulate the data in the team’s electronic lab notebook
• Learn & contribute to mass analysis of gRNA to identify molecular weight of the full-length product and related impurities
• Assist senior scientists with buffer preparation, instrument maintenance, and development of up-to-date analytical methods to help increase in-process analytical capacity
• Oversee stock of critical reagents for buffer preparation to support purification and analytics
• Coordinate with scientists to manage inventory of the final released materials

Qualifications

• Required: B.S. or M.S. candidate in Chemistry, Biochemistry, or related subjects; basic knowledge of organic chemistry preferred
• Required: Prior completion of general chemistry and lab courses
• Required: Excellent written and oral communication skills, strong organizational skills, ability to multi-task, and capacity to work independently or as part of a team
• Required: A passion for learning and contributing across multiple facets of a program
• Preferred: Relevant internship/Co-op experience
• Preferred: Completion of analytical chemistry lecture and lab courses
• Preferred: Familiarity working in a chemistry laboratory and experience with instrumentation such as HPLC, LC-MS, NanoDrop, and ÄKTA Pure