Small Scale Synthesis, Oligonucleotide Synthesis and Chemistry Co-op (Fall 2026)

Role Summary

Wave Life Sciences invites a motivated co-op to join our Small Scale Synthesis, Oligonucleotide Synthesis and Chemistry team in Lexington, MA for Fall 2026. The role offers exposure to oligonucleotide synthesis, formulation, purification, and analysis, with training across laboratory techniques and instrumentation. The position is well-suited for students who thrive in a fast-paced, team-oriented biotech environment and have strong organizational skills and attention to detail. Coursework in organic chemistry is required; biochemistry and analytical chemistry are preferred.

Responsibilities

• Prepare reagents and amidites for oligonucleotide synthesis
• Learn about solid phase synthesis and operate a Mermade192X synthesizer
• Purify oligonucleotides by preparative HPLC
• Analyze oligonucleotides by LC-MS, UV and pH
• Learn additional instrumentation including lyophilizers, speed vacs, nanodrop and UPLC
• Gain exposure to the use of an automated liquid handler for high throughput plate-based sample preparation
• Record and present data in an electronic laboratory notebook (ELN)

Qualifications

• Required: Currently enrolled in an undergraduate or graduate science program in Chemistry, Biology, Biotechnology or related field
• Required: Coursework in organic chemistry is required
• Preferred: Biochemistry and analytical chemistry are a plus
• Required: Understanding of laboratory best practices and safety protocols
• Required: Attention to detail and well organized
• Preferred: Laboratory experience with common laboratory operations including pipetting, weighing, and centrifugation
• Preferred: Enthusiasm for DNA/RNA therapeutic development