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Senior Staff Bioinformatics Scientist -- DNA/RNA Secondary Analysis Algorithms

Illumina
September 02, 2026
Full-time
Remote friendly (San Diego, CA)
Worldwide
Other
Role: Senior Staff Bioinformatics Scientist specializing in transcriptomics and multiomic analysis within Illumina's DRAGEN Bioinformatics team, focusing on developing advanced algorithms and software for DNA and RNA sequencing applications. Responsibilities: lead design and implementation of scalable workflows for bulk and single-cell RNA-seq, CRISPR/Perturb-seq, ATAC-seq, and emerging multiomic assays; apply machine learning and AI methods to accelerate development and innovation; collaborate across bioinformatics, software, and assay teams; provide technical leadership, mentorship, and influence product strategies; evaluate new technologies for IP opportunities. Requirements: PhD in Bioinformatics, Computational Biology, or related field with 8+ years of industry experience; proven expertise in developing bioinformatics algorithms, statistical modeling, and software for NGS data; proficiency in programming languages like Python or C++; experience with ML/AI techniques and cloud computing; strong communication skills and history of technical leadership. Preferred: experience with gene expression, splicing, fusion detection, single-cell workflows, CRISPR analysis, AI-assisted software development, and knowledge of oncology or clinical genomics. HighValue: focus on transcriptomics, multiomics, AI integration, large-scale genomic data processing, and product development in genomics. WorkSetup: not specified, likely collaborative, innovation-driven environment based in the US.