Senior Specialist, Quantitative Pharmacology and Pharmacometrics – Immuno-Oncology (QP2‑IO)
Merck
August 18, 2026
Remote friendly (Upper Gwynedd, PA)
United States
Clinical Research and Development
Role Overview
- Senior Scientist (Quantitative Pharmacology and Pharmacometrics – Immune/Oncology, QP2-IO) supporting oncology pipelines.
Primary Responsibilities
- Contribute to model-based strategies (translational PK/PD, mechanistic models, POPPK/PD, clinical trial simulations) to support quantitative analyses across programs to inform and optimize drug discovery and all phases of development (dose selection, trial design, go/no-go decisions).
- Represent QP2-IO on oncology discovery, early clinical development, and late clinical development teams using quantitative approaches to streamline programs.
- Collaborate with functional areas and external partners/vendors on study design, protocol development, execution, and reporting/interpretation of data.
Minimum Education
- Ph.D. with 0–2 years experience; OR
- PharmD or MS or equivalent with preferably 2–4 years of relevant experience (increasing responsibility/independence in drug development, regulatory agency, or academia).
Required Experience & Skills
- Background in biopharmaceutics/pharmaceutical sciences/pharmacometr ic s/chemical or biomedical engineering (or related).
- Experience performing population PK and PK/PD analyses using software such as NONMEM, Monolix, or Phoenix.
- Strong written/verbal communication; interdisciplinary collaboration; problem scoping and planning.
Preferred
- Oncology clinical drug development program knowledge.
- Experimental design, mathematical problem solving, critical data analysis/interpretation, and statistics.
- Understanding of biopharmaceutical and ADME properties of small molecules and/or biologics.
Skills (from posting)
- Communication, Data Modeling, Data Visualization, Drug Development, Model Development, Modeling Software, Pharmacometrics.
Preferred Skills
- ADME, Biologics, Biopharmaceutical Research, Biopharmaceuticals, Clinical Development, Clinical Trial Designs.
Application Instructions
- Apply via https://jobs.merck.com/us/en (or Workday Jobs Hub for current employees). Application deadline is stated on the posting. Requisition ID: R408370.
- Senior Scientist (Quantitative Pharmacology and Pharmacometrics – Immune/Oncology, QP2-IO) supporting oncology pipelines.
Primary Responsibilities
- Contribute to model-based strategies (translational PK/PD, mechanistic models, POPPK/PD, clinical trial simulations) to support quantitative analyses across programs to inform and optimize drug discovery and all phases of development (dose selection, trial design, go/no-go decisions).
- Represent QP2-IO on oncology discovery, early clinical development, and late clinical development teams using quantitative approaches to streamline programs.
- Collaborate with functional areas and external partners/vendors on study design, protocol development, execution, and reporting/interpretation of data.
Minimum Education
- Ph.D. with 0–2 years experience; OR
- PharmD or MS or equivalent with preferably 2–4 years of relevant experience (increasing responsibility/independence in drug development, regulatory agency, or academia).
Required Experience & Skills
- Background in biopharmaceutics/pharmaceutical sciences/pharmacometr ic s/chemical or biomedical engineering (or related).
- Experience performing population PK and PK/PD analyses using software such as NONMEM, Monolix, or Phoenix.
- Strong written/verbal communication; interdisciplinary collaboration; problem scoping and planning.
Preferred
- Oncology clinical drug development program knowledge.
- Experimental design, mathematical problem solving, critical data analysis/interpretation, and statistics.
- Understanding of biopharmaceutical and ADME properties of small molecules and/or biologics.
Skills (from posting)
- Communication, Data Modeling, Data Visualization, Drug Development, Model Development, Modeling Software, Pharmacometrics.
Preferred Skills
- ADME, Biologics, Biopharmaceutical Research, Biopharmaceuticals, Clinical Development, Clinical Trial Designs.
Application Instructions
- Apply via https://jobs.merck.com/us/en (or Workday Jobs Hub for current employees). Application deadline is stated on the posting. Requisition ID: R408370.