Senior Specialist, Quantitative Pharmacology and Pharmacometrics – Immuno-Oncology (QP2‑IO)
Merck
August 18, 2026
Remote friendly (Rahway, NJ)
United States
Clinical Research and Development
Role Overview
- Senior Scientist (Quantitative Pharmacology and Pharmacometrics – Immune/Oncology, QP2-IO) to support oncology pipelines.
Primary Responsibilities
- Develop model-based strategies (translational PK/PD, mechanistic models, POPPK/PD, clinical trial simulations) to inform and optimize drug discovery and all phases of development, including dose selection, clinical trial design, and go/no-go decisions.
- Represent QP2-IO across oncology discovery and early/late clinical development teams using quantitative approaches to streamline programs.
- Collaborate with internal functions and external vendors/partners on study design, protocol development, study execution, and reporting/interpretation of data.
Minimum Education
- Ph.D. with 0–2 years’ experience; or
- PharmD or MS (or equivalent), preferably 2–4 years of relevant experience with increasing responsibility/independence in drug development, regulatory agency, or academia.
Required Skills/Experience
- Background in biopharmaceutics, pharmaceutical sciences, pharmacometrics, chemical/biomedical engineering, or related field.
- Experience performing population PK and PK/PD analyses using standard pharmacometrics software (e.g., NONMEM, Monolix, Phoenix).
- Strong written/verbal communication, interdisciplinary collaboration, and problem scoping/planning.
Preferred
- Knowledge of oncology clinical drug development programs.
- Skills in experimental design, mathematical problem solving, critical data analysis/interpretation, and statistics.
- Understanding of biopharmaceutical and ADME properties of small molecules and/or biologics.
Skills (listed)
- Communication, Data Modeling, Data Visualization, Drug Development, Model Development, Modeling Software, Pharmacometrics.
Application
- Apply at https://jobs.merck.com/us/en (or Workday Jobs Hub if a current employee).
- Senior Scientist (Quantitative Pharmacology and Pharmacometrics – Immune/Oncology, QP2-IO) to support oncology pipelines.
Primary Responsibilities
- Develop model-based strategies (translational PK/PD, mechanistic models, POPPK/PD, clinical trial simulations) to inform and optimize drug discovery and all phases of development, including dose selection, clinical trial design, and go/no-go decisions.
- Represent QP2-IO across oncology discovery and early/late clinical development teams using quantitative approaches to streamline programs.
- Collaborate with internal functions and external vendors/partners on study design, protocol development, study execution, and reporting/interpretation of data.
Minimum Education
- Ph.D. with 0–2 years’ experience; or
- PharmD or MS (or equivalent), preferably 2–4 years of relevant experience with increasing responsibility/independence in drug development, regulatory agency, or academia.
Required Skills/Experience
- Background in biopharmaceutics, pharmaceutical sciences, pharmacometrics, chemical/biomedical engineering, or related field.
- Experience performing population PK and PK/PD analyses using standard pharmacometrics software (e.g., NONMEM, Monolix, Phoenix).
- Strong written/verbal communication, interdisciplinary collaboration, and problem scoping/planning.
Preferred
- Knowledge of oncology clinical drug development programs.
- Skills in experimental design, mathematical problem solving, critical data analysis/interpretation, and statistics.
- Understanding of biopharmaceutical and ADME properties of small molecules and/or biologics.
Skills (listed)
- Communication, Data Modeling, Data Visualization, Drug Development, Model Development, Modeling Software, Pharmacometrics.
Application
- Apply at https://jobs.merck.com/us/en (or Workday Jobs Hub if a current employee).