Senior Specialist, Quantitative Pharmacology and Pharmacometrics - Cardiometabolic and Ophthalmic Diseases
Merck
August 29, 2026
Remote friendly (West Point, PA)
United States
Clinical Research and Development
Responsibilities:
- Develop model-based strategies (translational PK/PD, mechanistic models, POPPK/PD, clinical trial simulations) to inform and optimize drug discovery and development decisions, including dose selection, trial design, and go/no-go.
- Represent QP2 across cardiometabolic and ophthalmology discovery and clinical development teams, using quantitative approaches to streamline programs.
- Collaborate with internal functions and external vendors/partners on study design, protocol development, execution, and data reporting/interpretation.
Required:
- Ph.D. (or equivalent) OR PharmD (or equivalent) with at least 2 years’ experience OR MS (or equivalent) with at least 4 years’ experience (increasing responsibility/independence in pharmaceutical drug development, regulatory agency, or academia).
- Background in biopharmaceutics, pharmaceutical sciences, pharmacometrics, chemical/biomedical engineering, or related field.
- Experience with population PK and PK/PD analyses using standard pharmacometrics software (e.g., NONMEM, Monolix, Phoenix).
- Strong written/verbal communication, interdisciplinary collaboration, and problem scoping/planning.
Preferred:
- Knowledge of cardiometabolic and/or ophthalmology clinical drug development programs.
- Skills in experimental design, mathematical problem solving, critical data analysis/interpretation, and statistics.
- Understanding of biopharmaceutical and ADME properties of small molecules and/or biologics.
You can apply at https://jobs.merck.com/us/en (or Workday Jobs Hub for current employees). Apply by the posting’s stated deadline.
- Develop model-based strategies (translational PK/PD, mechanistic models, POPPK/PD, clinical trial simulations) to inform and optimize drug discovery and development decisions, including dose selection, trial design, and go/no-go.
- Represent QP2 across cardiometabolic and ophthalmology discovery and clinical development teams, using quantitative approaches to streamline programs.
- Collaborate with internal functions and external vendors/partners on study design, protocol development, execution, and data reporting/interpretation.
Required:
- Ph.D. (or equivalent) OR PharmD (or equivalent) with at least 2 years’ experience OR MS (or equivalent) with at least 4 years’ experience (increasing responsibility/independence in pharmaceutical drug development, regulatory agency, or academia).
- Background in biopharmaceutics, pharmaceutical sciences, pharmacometrics, chemical/biomedical engineering, or related field.
- Experience with population PK and PK/PD analyses using standard pharmacometrics software (e.g., NONMEM, Monolix, Phoenix).
- Strong written/verbal communication, interdisciplinary collaboration, and problem scoping/planning.
Preferred:
- Knowledge of cardiometabolic and/or ophthalmology clinical drug development programs.
- Skills in experimental design, mathematical problem solving, critical data analysis/interpretation, and statistics.
- Understanding of biopharmaceutical and ADME properties of small molecules and/or biologics.
You can apply at https://jobs.merck.com/us/en (or Workday Jobs Hub for current employees). Apply by the posting’s stated deadline.