Senior Scientist, Transplant Immunology & Gene Therapy
United Therapeutics Corporation
3 hours ago
On-site
Silver Spring, MD
Clinical Research and Development
Responsibilities:
- Design and execute studies focused on innate and adaptive immune responses in donor and engineered lungs during EVLP
- Evaluate immunomodulatory strategies to improve lung preservation, reduce inflammation, and enhance post-transplant outcomes
- Assist with gene delivery strategies (AAV, lentiviral, adenoviral, mRNA/LNP, or other platforms) for lung-directed therapies
- Optimize transduction efficiency, durability of expression, and immunologic safety profiles
- Characterize immune cell populations and inflammatory pathways using flow cytometry, multiplex cytokine assays, transcriptomics, and histology
- Support preclinical transplant studies (experimental design, tissue analysis, and data interpretation)
- Develop and validate molecular/functional assays (qPCR, ddPCR, ELISA, flow cytometry, multiplex assays)
- Collaborate cross-functionally with device, manufacturing, analytical, translational, and regulatory teams
- Contribute to IND-enabling studies and regulatory documentation
- Mentor junior scientists and research associates
- Contribute to publications/patents/protocols and present data internally and externally
- Assist with EVLP procedures and translational lung studies
Minimum Requirements:
- Master’s degree in immunology, transplant biology, molecular biology, pulmonary biology, gene therapy, or related field
- 8+ years related biotech/pharma experience (Master’s) or 5+ years (PhD)
- Strong immunology background (immune cell biology, inflammatory signaling, or transplant immunology)
- Experience with viral vector systems (AAV, LVV, AdV) or non-viral gene delivery
- Experience developing immunologic/molecular assays (flow cytometry, cytokine profiling)
- Strong experimental design, data analysis, and communication skills
- Ability to work independently and in multidisciplinary teams; analytical/problem-solving skills; ability to mentor
Preferred Qualifications:
- PhD in relevant field
- Experience with lung transplantation, EVLP, or thoracic organ preservation
- Experience in transplant immunology/immune modulation and pulmonary/transplant gene therapy platforms
- Industry experience in cell/gene therapy; experience with human tissue and translational preclinical models
- Familiarity with IND-enabling studies and regulatory interactions
- Design and execute studies focused on innate and adaptive immune responses in donor and engineered lungs during EVLP
- Evaluate immunomodulatory strategies to improve lung preservation, reduce inflammation, and enhance post-transplant outcomes
- Assist with gene delivery strategies (AAV, lentiviral, adenoviral, mRNA/LNP, or other platforms) for lung-directed therapies
- Optimize transduction efficiency, durability of expression, and immunologic safety profiles
- Characterize immune cell populations and inflammatory pathways using flow cytometry, multiplex cytokine assays, transcriptomics, and histology
- Support preclinical transplant studies (experimental design, tissue analysis, and data interpretation)
- Develop and validate molecular/functional assays (qPCR, ddPCR, ELISA, flow cytometry, multiplex assays)
- Collaborate cross-functionally with device, manufacturing, analytical, translational, and regulatory teams
- Contribute to IND-enabling studies and regulatory documentation
- Mentor junior scientists and research associates
- Contribute to publications/patents/protocols and present data internally and externally
- Assist with EVLP procedures and translational lung studies
Minimum Requirements:
- Master’s degree in immunology, transplant biology, molecular biology, pulmonary biology, gene therapy, or related field
- 8+ years related biotech/pharma experience (Master’s) or 5+ years (PhD)
- Strong immunology background (immune cell biology, inflammatory signaling, or transplant immunology)
- Experience with viral vector systems (AAV, LVV, AdV) or non-viral gene delivery
- Experience developing immunologic/molecular assays (flow cytometry, cytokine profiling)
- Strong experimental design, data analysis, and communication skills
- Ability to work independently and in multidisciplinary teams; analytical/problem-solving skills; ability to mentor
Preferred Qualifications:
- PhD in relevant field
- Experience with lung transplantation, EVLP, or thoracic organ preservation
- Experience in transplant immunology/immune modulation and pulmonary/transplant gene therapy platforms
- Industry experience in cell/gene therapy; experience with human tissue and translational preclinical models
- Familiarity with IND-enabling studies and regulatory interactions