Senior Scientist, Translational Science & Diagnostics (TSDx)
Bicycle Therapeutics
5 hours ago
Remote friendly (Lexington, MA)
United States
$126,000 - $1,570,000 USD yearly
Clinical Research and Development
Job Description
Your mission is to apply your scientific expertise to the design, execution, and analyses of translational data packages derived for assets in our clinical oncology portfolio. You will develop and analyze biomarker assay data from multiple modalities (IHC, NGS, FISH, imaging, etc.) and contribute to advancing Bicycle Drug Conjugates (BDCs) and Bicycle Radio Conjugates (BRCs) from discovery into the clinic, including companion diagnostics development.
Scientific Strategy & Innovation
- Contribute to the design and execution of translational strategies aligned with project goals, focusing on robust biomarker packages for patient selection, proof-of-mechanism, and pharmacodynamic assessment.
- Represent the TSDx department on global project teams for nuzefatide pevedotin (BT5528) and zelenectide pevedotin (BT8009) to execute prioritized team biomarker strategy.
- Identify and champion innovation opportunities across biomarker analytical methodologies.
Project Delivery & Execution
- Independently perform and oversee quantitative analysis of biomarker data sets from clinical studies, including management of third-party laboratory activities (e.g., CROs and/or academic collaborators) to ensure high-quality, timely, interpretable results.
- Lead authorship of biomarker sections of team technical documents (e.g., clinical protocols, investigator brochure, lab manual, regulatory briefing books as required) and pursue opportunities to publish clinical biomarker data externally.
- Present scientific findings and interpretations clearly at project team meetings and to cross-functional stakeholders.
Qualifications
- Demonstrated expertise designing, delivering, analyzing, and interpreting clinical biomarker data (e.g., IHC, NGS, FISH, imaging, etc.) in oncology clinical trials (solid or liquid tumors).
- Demonstrated capability delivering clinical biomarker assay development at third-party laboratories within clinical trials (biomarker lead experience on global oncology project teams highly desirable).
- Familiarity with regulatory requirements for clinical biomarker studies, including up to companion diagnostics (advantage).
- Advanced degree (MS, PhD, or equivalent) in a relevant scientific discipline (preferred).
Additional Skills/Behaviors (from job description)
- Independently interprets complex clinical biomarker data; identifies patterns, draws conclusions, and understands project implications.
- Shares learnings and mentors more junior colleagues.
- Anticipates scientific challenges and develops practical, creative solutions.
- Operates independently with minimal supervision; uses sound scientific judgment for method selection and decision-making.
Benefits (explicitly listed)
- Flexible working environment
- Competitive reward including annual company bonus
- Medical, dental, and vision insurance for eligible employees and their families (100% of premiums covered by the company)
- Health and Dependent Care Flexible Spending Accounts
- 401(k) plan with 4% company match and immediate vesting
- Up to 23 paid time off days per full year worked; option to buy up to 5 additional days
- Employee assistance program; employee recognition schemes
- 10 company holidays
- Competitive Family Leave Policy
- Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc
Compensation (explicitly listed)
- Salary Range: $126,000 - $157,000
Your mission is to apply your scientific expertise to the design, execution, and analyses of translational data packages derived for assets in our clinical oncology portfolio. You will develop and analyze biomarker assay data from multiple modalities (IHC, NGS, FISH, imaging, etc.) and contribute to advancing Bicycle Drug Conjugates (BDCs) and Bicycle Radio Conjugates (BRCs) from discovery into the clinic, including companion diagnostics development.
Scientific Strategy & Innovation
- Contribute to the design and execution of translational strategies aligned with project goals, focusing on robust biomarker packages for patient selection, proof-of-mechanism, and pharmacodynamic assessment.
- Represent the TSDx department on global project teams for nuzefatide pevedotin (BT5528) and zelenectide pevedotin (BT8009) to execute prioritized team biomarker strategy.
- Identify and champion innovation opportunities across biomarker analytical methodologies.
Project Delivery & Execution
- Independently perform and oversee quantitative analysis of biomarker data sets from clinical studies, including management of third-party laboratory activities (e.g., CROs and/or academic collaborators) to ensure high-quality, timely, interpretable results.
- Lead authorship of biomarker sections of team technical documents (e.g., clinical protocols, investigator brochure, lab manual, regulatory briefing books as required) and pursue opportunities to publish clinical biomarker data externally.
- Present scientific findings and interpretations clearly at project team meetings and to cross-functional stakeholders.
Qualifications
- Demonstrated expertise designing, delivering, analyzing, and interpreting clinical biomarker data (e.g., IHC, NGS, FISH, imaging, etc.) in oncology clinical trials (solid or liquid tumors).
- Demonstrated capability delivering clinical biomarker assay development at third-party laboratories within clinical trials (biomarker lead experience on global oncology project teams highly desirable).
- Familiarity with regulatory requirements for clinical biomarker studies, including up to companion diagnostics (advantage).
- Advanced degree (MS, PhD, or equivalent) in a relevant scientific discipline (preferred).
Additional Skills/Behaviors (from job description)
- Independently interprets complex clinical biomarker data; identifies patterns, draws conclusions, and understands project implications.
- Shares learnings and mentors more junior colleagues.
- Anticipates scientific challenges and develops practical, creative solutions.
- Operates independently with minimal supervision; uses sound scientific judgment for method selection and decision-making.
Benefits (explicitly listed)
- Flexible working environment
- Competitive reward including annual company bonus
- Medical, dental, and vision insurance for eligible employees and their families (100% of premiums covered by the company)
- Health and Dependent Care Flexible Spending Accounts
- 401(k) plan with 4% company match and immediate vesting
- Up to 23 paid time off days per full year worked; option to buy up to 5 additional days
- Employee assistance program; employee recognition schemes
- 10 company holidays
- Competitive Family Leave Policy
- Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc
Compensation (explicitly listed)
- Salary Range: $126,000 - $157,000