Senior Scientist, Translational PK/PD
Merck
August 14, 2026
Remote friendly (West Point, PA)
United States
Clinical Research and Development
The department of Pharmacokinetics, Dynamics, Metabolism & Bioanalytics (PDMB) is seeking a Senior Scientist for its Translational PK/PD organization. The role designs and executes analyses, guiding drug discovery strategy focused on biologics, protein therapeutics, and peptides.
The Translational PK/PD Senior Scientist will:
- Serve as PK/PD modeler in cross-functional teams to make model-informed decisions about drug discovery, modality selection, and dose prediction.
- Integrate in vitro and in vivo data to build PKPD, PBPK, QSP, or other mechanistic modeling platforms for drug disposition and pharmacology.
- Collaborate with PDMB and Discovery/Translational teams to design experimental studies and modeling plans to identify and optimize drug candidates.
- Collaborate on automated workflows for implementing modeling platforms to inform human PK/PD and dose projections.
- With guidance, build expertise and leadership in translational modeling and drug discovery; demonstrate strong communication and leadership skills.
Qualifications:
- Master’s (3+ years), PharmD (1 year), or Ph.D. in pharmacokinetics/pharmacodynamics, mathematics, applied mathematics, systems biology, computational biology, chemical/biomedical engineering, statistics/biostatistics or related field, with increasing responsibility/independence.
Required experience/skills:
- Hands-on translational PKPD modeling using Matlab, OSP Suite, Monolix, or R.
- Experimental design, mathematical problem solving, and critical data analysis/interpretation and/or statistics.
Preferred experience/skills:
- Modeling experience informing discovery/development of biologics/protein therapeutics/peptides.
- Interdisciplinary teamwork.
- Expertise developing novel PKPD, PBPK, QSP, or related mechanistic approaches.
Skills: Biostatistics, data analysis, data modeling, data science, drug discovery process, interdisciplinary collaboration, MATLAB, pharmacodynamics/pharmacokinetics, PKPD modeling, statistical analysis.
Application: Apply via https://jobs.merck.com/us/en.
The Translational PK/PD Senior Scientist will:
- Serve as PK/PD modeler in cross-functional teams to make model-informed decisions about drug discovery, modality selection, and dose prediction.
- Integrate in vitro and in vivo data to build PKPD, PBPK, QSP, or other mechanistic modeling platforms for drug disposition and pharmacology.
- Collaborate with PDMB and Discovery/Translational teams to design experimental studies and modeling plans to identify and optimize drug candidates.
- Collaborate on automated workflows for implementing modeling platforms to inform human PK/PD and dose projections.
- With guidance, build expertise and leadership in translational modeling and drug discovery; demonstrate strong communication and leadership skills.
Qualifications:
- Master’s (3+ years), PharmD (1 year), or Ph.D. in pharmacokinetics/pharmacodynamics, mathematics, applied mathematics, systems biology, computational biology, chemical/biomedical engineering, statistics/biostatistics or related field, with increasing responsibility/independence.
Required experience/skills:
- Hands-on translational PKPD modeling using Matlab, OSP Suite, Monolix, or R.
- Experimental design, mathematical problem solving, and critical data analysis/interpretation and/or statistics.
Preferred experience/skills:
- Modeling experience informing discovery/development of biologics/protein therapeutics/peptides.
- Interdisciplinary teamwork.
- Expertise developing novel PKPD, PBPK, QSP, or related mechanistic approaches.
Skills: Biostatistics, data analysis, data modeling, data science, drug discovery process, interdisciplinary collaboration, MATLAB, pharmacodynamics/pharmacokinetics, PKPD modeling, statistical analysis.
Application: Apply via https://jobs.merck.com/us/en.