Senior Scientist - Targeted Protein Degradation

Role Summary

Senior Scientist - Targeted Protein Degradation. Lead discovery efforts in molecular glue degraders and establish phenotypic-based screening platforms within Amgen's Induced Proximity Platform (IPP) to advance targeted protein degradation technologies for high-value targets in oncology, inflammation, and related areas.

Responsibilities

• Design, establish, and implement phenotypic-based screening platforms to enable discovery of novel induced proximity mechanisms.
• Develop and optimize assays that capture cellular context, functional outcomes, and disease relevance.
• Work with automation and high-throughput screening teams to scale phenotypic platforms for broader application across IPP.
• Integrate advanced imaging, omics, and data science approaches to extract actionable biological insights from phenotypic screens.
• Apply diverse experimental approaches, including biochemical, biophysical, and cell biology techniques, to understand degrader mechanisms of action.
• Partner with cross-functional teams across IPP and external collaborators to broaden the scope of induced proximity drug discovery.
• Share insights through internal presentations, publications, and external conferences.
• Provide scientific mentorship to junior scientists and contribute to fostering an environment of curiosity and innovation.

Qualifications

• Basic Qualifications:
  • Doctorate degree (PhD or PharmD or MD) and relevant post-doctoral experience, or
  • Master‚Äôs degree with 3 years of directly related experience, or
  • Bachelor‚Äôs degree with 5 years of directly related experience
• Preferred Qualifications:
  • PhD in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field, with postdoctoral training or equivalent industry experience.
  • 2+ years of relevant industry experience (biotechnology or pharmaceutical research).
  • Demonstrated expertise in targeted protein degradation, molecular glue biology, or proximity-based drug discovery.
  • Hands-on experience developing and executing cellular assays or phenotypic screening approaches.
  • Track record of assay development for high-content or high-throughput phenotypic screening, including use of automation and advanced imaging technologies.
  • Proficiency in cellular and molecular biology techniques, such as CRISPR perturbations, proteomics, or transcriptomics applied to phenotypic readouts.
  • Experience applying systems biology and data integration approaches to interpret complex phenotypic datasets.
  • Strong scientific creativity with a record of publications, patents, or conference presentations in relevant fields.
  • Excellent interpersonal and communication skills; ability to work collaboratively in a matrixed research environment.

Skills

• Phenotypic screening, high-content imaging, and data analysis
• Cell biology, biochemistry, and molecular biology techniques
• CRISPR-based perturbations, proteomics, transcriptomics
• Automation and high-throughput screening
• Cross-functional collaboration and scientific mentorship

Education

• PhD or equivalent in a related scientific field preferred for advanced roles; relevant industry experience considered.