Senior Scientist - Targeted Protein Degradation

Role Summary

Senior Scientist within Amgen's Induced Proximity Platform (IPP) focusing on Targeted Protein Degradation. You will support discovery and development of molecular glue degraders for high-value targets, establish and execute phenotypic-based screening platforms, and collaborate across IPP and partner functions to advance proximity-based drug discovery. The position blends mechanistic biology with phenotypic screening to identify novel therapeutic opportunities while shaping platform capabilities from the bench.

Responsibilities

• Design, establish, and implement phenotypic-based screening platforms to enable discovery of novel induced proximity mechanisms.
• Develop and optimize assays that capture cellular context, functional outcomes, and disease relevance.
• Work with automation and high-throughput screening teams to scale phenotypic platforms for broader application across IPP.
• Integrate advanced imaging, omics, and data science approaches to extract actionable biological insights from phenotypic screens.
• Apply diverse experimental approaches, including biochemical, biophysical, and cell biology techniques, to understand degrader mechanisms of action.
• Partner with cross-functional teams across IPP and external collaborators to broaden the scope of induced proximity drug discovery.
• Share insights through internal presentations, publications, and external conferences.
• Provide scientific mentorship to junior scientists and contribute to fostering an environment of curiosity and innovation.

Qualifications

• Required: Doctorate degree (PhD OR PharmD OR MD) [and relevant post-doc where applicable]
• Required: Master’s degree and 3 years of directly related experience
• Required: Bachelor’s degree and 5 years of directly related experience
• Preferred: PhD in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field, with postdoctoral training or equivalent industry experience.
• Preferred: 2+ years of relevant industry experience (biotechnology or pharmaceutical research).
• Preferred: Demonstrated expertise in targeted protein degradation, molecular glue biology, or proximity-based drug discovery.
• Preferred: Hands-on experience developing and executing cellular assays or phenotypic screening approaches.
• Preferred: Track record of assay development for high-content or high-throughput phenotypic screening, including use of automation and advanced imaging technologies.
• Preferred: Proficiency in cellular and molecular biology techniques, such as CRISPR-based perturbations, proteomics, or transcriptomics applied to phenotypic readouts.
• Preferred: Experience applying systems biology and data integration approaches to interpret complex phenotypic datasets.
• Preferred: Strong scientific creativity with a record of publications, patents, or conference presentations in relevant fields.
• Preferred: Excellent interpersonal and communication skills; ability to work collaboratively in a matrixed research environment.

Education

• Doctorate degree (PhD, PharmD, or MD) with relevant post-doctoral research experience
• Master’s degree with 3 years of directly related experience
• Bachelor’s degree with 5 years of directly related experience