Senior Scientist - Targeted Protein Degradation

Role Summary

Senior Scientist within Amgen’s Induced Proximity Platform (IPP) focusing on targeted protein degradation and molecular glue degraders. You will design and execute phenotypic-based screening platforms, develop assays, and collaborate cross-functionally to advance discovery of novel therapeutics.

Responsibilities

• Design, establish, and implement phenotypic-based screening platforms to enable discovery of novel induced proximity mechanisms.
• Develop and optimize assays that capture cellular context, functional outcomes, and disease relevance.
• Work with automation and high-throughput screening teams to scale phenotypic platforms for broader application across IPP.
• Integrate advanced imaging, omics, and data science approaches to extract actionable biological insights from phenotypic screens.
• Apply diverse experimental approaches, including biochemical, biophysical, and cell biology techniques, to understand degrader mechanisms of action.
• Partner with cross-functional teams across IPP and external collaborators to broaden the scope of induced proximity drug discovery.
• Share insights through internal presentations, publications, and external conferences.
• Provide scientific mentorship to junior scientists and contribute to fostering an environment of curiosity and innovation.

Qualifications

• Required: Doctorate degree (PhD or PharmD or MD) or equivalent; or Master’s degree with 3 years of directly related experience; or Bachelor’s degree with 5 years of directly related experience.
• Preferred: PhD in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field with postdoctoral training or equivalent industry experience.
• Preferred: 2+ years of relevant industry experience in biotechnology or pharmaceutical research.
• Preferred: Demonstrated expertise in targeted protein degradation, molecular glue biology, or proximity-based drug discovery.
• Preferred: Hands-on experience developing and executing cellular assays or phenotypic screening approaches.
• Preferred: Track record of assay development for high-content or high-throughput phenotypic screening, including use of automation and advanced imaging technologies.
• Preferred: Proficiency in cellular and molecular biology techniques (e.g., CRISPR perturbations, proteomics, transcriptomics) applied to phenotypic readouts.
• Preferred: Experience applying systems biology and data integration to interpret complex phenotypic datasets.
• Preferred: Strong scientific creativity with publications, patents, or conference presentations; excellent interpersonal and communication skills for collaboration.

Education

• Doctorate degree (PhD) or equivalent required; or Master’s degree with 3 years of related experience; or Bachelor’s degree with 5 years of related experience.