Senior Scientist - Targeted Protein Degradation

Role Summary

Senior Scientist to support Molecular Glues discovery and to establish and execute phenotypic-based screening platforms within Amgen’s Induced Proximity Platform (IPP). This dual focus role advances Amgen’s strategy in emerging proximity technologies and provides the opportunity to lead from the bench while shaping platform capabilities that enable broad discovery efforts. The position emphasizes innovation, collaboration, and integration of mechanistic biology with phenotypic screening to discover novel therapeutic opportunities.

Responsibilities

• Design, establish, and implement phenotypic-based screening platforms to enable discovery of novel induced proximity mechanisms.
• Develop and optimize assays that capture cellular context, functional outcomes, and disease relevance.
• Work with automation and high-throughput screening teams to scale phenotypic platforms for broader application across IPP.
• Integrate advanced imaging, omics, and data science approaches to extract actionable biological insights from phenotypic screens.
• Apply diverse experimental approaches, including biochemical, biophysical, and cell biology techniques, to understand degrader mechanisms of action.
• Partner with cross-functional teams across IPP and external collaborators to broaden the scope of induced proximity drug discovery.
• Share insights through internal presentations, publications, and external conferences.
• Provide scientific mentorship to junior scientists and contribute to fostering an environment of curiosity and innovation.

Qualifications

• Required: Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] OR Master’s degree and 3 years of directly related experience OR Bachelor’s degree and 5 years of directly related experience.
• Preferred: PhD in Chemical Biology, Cell Biology, Biochemistry, Pharmacology, or related field, with postdoctoral training or equivalent industry experience.
• Preferred: 2+ years of relevant industry experience (biotechnology or pharmaceutical research).
• Preferred: Demonstrated expertise in targeted protein degradation, molecular glue biology, or proximity-based drug discovery.
• Preferred: Hands-on experience developing and executing cellular assays or phenotypic screening approaches.
• Preferred: Track record of assay development for high-content or high-throughput phenotypic screening, including use of automation and advanced imaging technologies.
• Preferred: Proficiency in cellular and molecular biology techniques, such as CRISPR-based perturbations, proteomics, or transcriptomics applied to phenotypic readouts.
• Preferred: Experience applying systems biology and data integration approaches to interpret complex phenotypic datasets.
• Preferred: Strong scientific creativity with a record of publications, patents, or conference presentations in relevant fields.
• Preferred: Excellent interpersonal and communication skills; ability to work collaboratively in a matrixed research environment.

Skills

• Targeted protein degradation, molecular glue biology, or proximity-based drug discovery.
• Hands-on experience developing and executing cellular assays or phenotypic screening approaches.
• High-content or high-throughput phenotypic screening, including use of automation and advanced imaging technologies.
• Proficiency in cellular and molecular biology techniques, such as CRISPR perturbations, proteomics, or transcriptomics applied to phenotypic readouts.
• Systems biology and data integration approaches to interpret complex phenotypic datasets.
• Strong scientific creativity with a record of publications, patents, or conference presentations in relevant fields.
• Excellent interpersonal and communication skills; ability to work collaboratively in a matrixed research environment.

Education

• Degree requirements: Doctorate degree (PhD/PharmD/MD) or Master's degree with 3 years directly related experience or Bachelor's degree with 5 years directly related experience; postdoctoral training where applicable.