Senior Scientist, siRNA Screening Automation and Molecular Analytics
AbbVie
June 24, 2026
On-site
Worcester, MA
$109,500 - $208,500 USD yearly
Clinical Research and Development
Job Responsibilities:
- Lead execution of high-throughput siRNA screening workflows using automated liquid-handling and other lab automation systems.
- Develop, optimize, and troubleshoot automated sample preparation methods (RNA extraction, RT-qPCR, RNA-seq library preparation).
- Design and execute experiments to evaluate siRNA activity, potency, and selectivity using molecular biology assay platforms.
- Establish and maintain data analysis workflows for screening datasets (assay QC, normalization, hit assessment, and result interpretation).
- Drive development and implementation of NGS-based strategies using automation for gene expression profiling.
- Partner with cross-functional scientists and bioinformatics to analyze and interpret large screening/sequencing datasets.
- Improve, standardize, and document screening workflows, assay protocols, and automation procedures.
- Proactively identify technical issues and implement solutions to improve assay robustness, throughput, and reproducibility.
- Present results, contribute to scientific discussions, and support experimental planning and strategy.
- Mentor junior scientists/research associates as needed.
Qualifications:
- BS/MS/PhD in Molecular Biology, Genomics, Bioinformatics, Bioengineering, or related field (0-4+ years PhD; 8-10+ years MS; 10-12+ years BS) in relevant biotech/pharma experience.
- Strong hands-on lab automation, high-throughput screening, and coding for automation systems.
- Deep experience with RNA extraction and RT-qPCR assay development/execution/troubleshooting.
- Familiarity with NGS workflows for library construction and gene expression profiling (including automation integration).
- Strongly preferred: siRNA screening/oligonucleotide therapeutics/RNA biology experience.
- Familiarity with scripting, data processing tools, or bioinformatics collaboration.
- Prior experience supporting platform buildout in a matrixed drug discovery environment.
- Strong organization, attention to detail, communication, and cross-functional collaboration.
Benefits (if applicable/explicitly stated): Paid time off; medical/dental/vision insurance; 401(k); short-term incentive eligible; possible long-term incentive plan eligibility.
- Lead execution of high-throughput siRNA screening workflows using automated liquid-handling and other lab automation systems.
- Develop, optimize, and troubleshoot automated sample preparation methods (RNA extraction, RT-qPCR, RNA-seq library preparation).
- Design and execute experiments to evaluate siRNA activity, potency, and selectivity using molecular biology assay platforms.
- Establish and maintain data analysis workflows for screening datasets (assay QC, normalization, hit assessment, and result interpretation).
- Drive development and implementation of NGS-based strategies using automation for gene expression profiling.
- Partner with cross-functional scientists and bioinformatics to analyze and interpret large screening/sequencing datasets.
- Improve, standardize, and document screening workflows, assay protocols, and automation procedures.
- Proactively identify technical issues and implement solutions to improve assay robustness, throughput, and reproducibility.
- Present results, contribute to scientific discussions, and support experimental planning and strategy.
- Mentor junior scientists/research associates as needed.
Qualifications:
- BS/MS/PhD in Molecular Biology, Genomics, Bioinformatics, Bioengineering, or related field (0-4+ years PhD; 8-10+ years MS; 10-12+ years BS) in relevant biotech/pharma experience.
- Strong hands-on lab automation, high-throughput screening, and coding for automation systems.
- Deep experience with RNA extraction and RT-qPCR assay development/execution/troubleshooting.
- Familiarity with NGS workflows for library construction and gene expression profiling (including automation integration).
- Strongly preferred: siRNA screening/oligonucleotide therapeutics/RNA biology experience.
- Familiarity with scripting, data processing tools, or bioinformatics collaboration.
- Prior experience supporting platform buildout in a matrixed drug discovery environment.
- Strong organization, attention to detail, communication, and cross-functional collaboration.
Benefits (if applicable/explicitly stated): Paid time off; medical/dental/vision insurance; 401(k); short-term incentive eligible; possible long-term incentive plan eligibility.