Senior Scientist, siRNA Design and Off-Target Analysis

Role: Senior Scientist in computational biology specializing in siRNA design and off-target assessment within AbbVie's Biotherapeutic and Genetic Medicine department. Primary objectives include optimizing siRNA sequences for enhanced efficacy and reduced off-target effects, developing workflows for off-target analysis, and integrating multi-omics data. Responsibilities encompass pipeline development for sequence design, machine learning model construction from high-throughput screening data, interpretation of transcriptomic signals, and collaboration with cross-functional teams including in vitro assay and AI scientists. Qualifications: BS/MS/PhD in genomics, RNA biology, or related field with 0-12+ years of biotech/pharma experience; proficiency in Python/R and NGS data analysis; experience supporting off-target and risk assessment for RNA-based modalities. Preferred skills include multi-omics data integration, RNAi mechanisms, and experience with machine learning workflows. High-value specifics: focus on RNA therapeutics, siRNA, off-target risk, transcriptomics, and nonclinical safety; potential for seniority level based on experience. Work setup and travel details are not specified.