Senior Scientist - siRNA Bioanalysis & Mechanistic Studies

Senior Scientist - siRNA Bioanalysis & Mechanistic Studies

What You Will Do
- Conduct bioanalysis of siRNA therapeutics in preclinical samples (in vitro and in vivo)
- Establish innovative in vitro ADME assays to characterize siRNA mechanism of action and generate mechanistic insights to support discovery programs
- Design, execute, and interpret in vivo studies characterizing pharmacokinetics, pharmacokinetic-pharmacodynamic relationships, tissue distribution, and toxicokinetics
- Foster cross-functional collaboration across Research and Development to advance siRNA therapeutics from discovery to clinical proof of concept

Basic Qualifications
- Doctorate degree (and relevant post-doc where applicable) in pharmacology, biochemistry, or a related scientific discipline
OR
- Master’s degree in pharmacology/biochemistry/related discipline and 3 years of industry experience
OR
- Bachelor’s degree in pharmacology/biochemistry/related discipline and 6 years of industry experience

Preferred Qualifications / Skills
- Extensive knowledge of siRNA therapeutics in the context of ADME and pharmacokinetics
- Experience designing/executing “fit-for-purpose” mechanistic assays for key scientific questions
- Hands-on experience with ligand binding assays (immunoassay, hybridization), LC/MS bioanalytical platforms, and nucleic acid quantification (RT-qPCR or RT-ddPCR)
- Strong critical thinking, problem-solving, and data interpretation
- Excellent written and verbal communication

Application Instructions
- Apply at careers.amgen.com; no application deadline (applications accepted until sufficient number or candidate selection).