Senior Scientist, Radiochemistry

Role Summary

Senior Scientist, Radiochemistry responsible for hands-on laboratory work focused on radiolabeling of antibodies and antibody fragments with radiometals, and conjugation of biomolecules with metal chelators. Supports preclinical research activities in cancer theranostics and therapeutic applications, contributing to translational development and early CMC scale-up. Serves as the site Radiation Safety Officer (RSO) and ensures compliance with radiation safety regulations and internal practices.

Responsibilities

• Radiochemistry & Conjugation
  • Perform and optimize radiolabeling of antibodies and antibody fragments with therapeutic and diagnostic radiometals.
  • Conjugate antibodies with metal chelators.
  • Develop reproducible and scalable labeling protocols for preclinical and translational applications.
  • Design and execute quality control assays (HPLC, iTLC, SEC, SDS-PAGE).
  • Develop and transfer analytical methods to support preclinical studies and CMC activities.
• Protein Biochemistry
  • Handle, purify, and characterize antibodies/proteins; assess integrity and stability after conjugation and radiolabeling.
  • Support analytical method development for protein-radiometal conjugates.
• Preclinical & Development Support
  • Collaborate with in-vivo biology team to support in vitro and in vivo studies.
  • Contribute to CMC scale-up activities and IND-enabling activities, including process documentation and technology transfer.
• Radiation Safety
  • Serve as the site‚Äôs Radiation Safety Officer (RSO).
  • Maintain compliance with radiation safety regulations; implement procedures, train staff, and maintain records and licenses.

Qualifications

• Required: Bachelor‚Äôs degree with 8+ years, Master‚Äôs with 6+ years, or PhD with 5+ years in Chemistry, Biochemistry, Radiochemistry, Pharmaceutical Sciences, or related field.
• 3+ years of laboratory experience in radiolabeling of biologics, metal chelator chemistry, and related QC techniques.
• Strong background in protein biochemistry including antibody purification, conjugation, and characterization.
• Experience with analytical methods used in radiopharmaceuticals and protein characterization.
• Prior or current qualification as Radiation Safety Officer (or equivalent experience).
• Knowledge of regulations governing radiation safety.
• Strong documentation, organizational, and communication skills.

• Preferred: Experience with preclinical radiopharmaceutical development in oncology; familiarity with CMC scale-up and regulatory documentation; experience in GMP or GLP environments.

Skills

• Safety Mindset
• Scientific Rigor
• Collaboration
• Accountability
• Adaptability
• Problem-Solving
• Communication

Education

• As listed under Qualifications (degree appropriate to field and years of experience).

Additional Requirements

• None beyond the above roles and qualifications.