Senior Scientist, Radiochemistry

Role Summary

Senior Scientist, Radiochemistry responsible for hands-on radiolabeling of antibodies and antibody fragments with radiometals and for the conjugation of biomolecules with metal chelators. This role requires a strong foundation in radiochemistry, protein biochemistry, and antibody characterization. Supports preclinical research activities in cancer theranostics and therapeutic applications, and contributes to translational development and early CMC scale-up initiatives. Serves as the site Radiation Safety Officer (RSO) and ensures compliance with radiation safety regulations and internal practices.

Responsibilities

• Radiochemistry & Conjugation
  • Perform and optimize radiolabeling of antibodies and antibody fragments with therapeutic and diagnostic radiometals (e.g., 177-Lu, 225-Ac, 89-Zr, 64-Cu, etc.).
  • Conduct chemical conjugation of antibodies with metal chelators (e.g., DOTA, DOTAGA, DTPA, DFO, MACROPA).
  • Develop reproducible and scalable labeling protocols for preclinical and translational applications.
  • Design and execute quality control assays (HPLC, iTLC, SEC, SDS-PAGE).
  • Develop and transfer analytical methods to support preclinical studies and CMC activities.
• Protein Biochemistry
  • Apply biochemical expertise in antibody/protein handling, purification, and characterization.
  • Assess protein integrity and stability following conjugation and radiolabeling.
  • Support analytical method development for protein-radiometal conjugates.
• Preclinical & Development Support
  • Collaborate with in-vivo biology team to support in vitro and in vivo studies.
  • Provide input into CMC scale-up activities.
  • Contribute to IND-enabling activities, including process documentation and technology transfer.
• Radiation Safety
  • Serve as the site’s Radiation Safety Officer (RSO).
  • Maintain compliance with local, state, and federal radiation safety regulations.
  • Implement radiation safety procedures, train laboratory staff, and maintain required records and licenses.

Qualifications

• Required:
  • Bachelors plus 8+ years, Masters plus 6+ years, Ph.D. plus 5+ years in Chemistry, Biochemistry, Radiochemistry, Pharmaceutical Sciences, or related field.
  • 3+ years of laboratory experience in radiolabeling of biologics, metal chelator chemistry, and related QC techniques.
  • Strong background in protein biochemistry, including antibody purification, conjugation, and characterization.
  • Experience with analytical methods commonly applied in radiopharmaceutical and protein characterization.
  • Prior or current qualification as Radiation Safety Officer (or equivalent experience).
  • Knowledge of regulations governing radiation safety.
  • Strong documentation, organizational, and communication skills.
• Preferred:
  • Experience with preclinical radiopharmaceutical development in oncology.
  • Familiarity with CMC scale-up activities and regulatory documentation.
  • Experience with GMP or GLP environments.

Skills

• Safety Mindset: Demonstrates strict adherence to radiation safety protocols and laboratory best practices.
• Scientific Rigor: Applies a detail-oriented and methodical approach to experimental design, execution, and data analysis.
• Collaboration: Works effectively across multidisciplinary teams, fostering open communication and knowledge sharing.
• Accountability: Takes ownership of projects and responsibilities, delivering on commitments in a timely manner.
• Adaptability: Adjusts to evolving project priorities, regulatory requirements, and organizational needs.
• Problem-Solving: Approaches technical challenges with creativity and persistence, identifying practical solutions.
• Communication: Clearly communicates experimental results, documentation, and regulatory materials to internal stakeholders and collaborators.