Senior Scientist, Protein Sciences (BS or MS)

Role Summary

Senior Scientist I with a strong background in protein biochemistry to focus on production of difficult protein targets enabling downstream biophysics, structural biology, and high-throughput screening. Design protein constructs for optimal expression, develop purification methodologies, and characterize proteins with biophysical and structural techniques. Collaborate across teams on novel and challenging drug-discovery projects.

Responsibilities

• Develop and execute protocols to produce various proteins targets for small molecule hit generation, hit validation and structural biology studies of protein-small molecule complexes.
• Design protein constructs based on literature and AI-powered structure prediction tools.
• Protein expression in mammalian and insect cell culture lines.
• Protein purification using various chromatography techniques and FPLC equipment.
• Collaborate with colleagues to characterize proteins using biophysical and structural biology techniques.
• Maintains a high level of professional expertise through accurate and detailed record keeping and familiarity with scientific literature.
• Work collaboratively with lab associates in a matrix setting to expand our protein production toolkit.
• Present and communicate results with protein science colleagues and project teams.

Qualifications

• BS or MS degree in biochemistry, life sciences, molecular biology or related field with at least 5 years of relevant post-graduate research laboratory experience. This is not a PhD-level position.
• Proven in-depth knowledge and hands-on experience in protein chemistry, including protein expression, purification, and characterization.
• Experience with molecular biology and protein sequence analysis.
• Demonstrated critical thinking and troubleshooting ability when handling challenging proteins
• Excellent collaboration, communication (oral and written) and organizational skills and the ability to present work formally to project teams and scientific research committees.
• Strong desire to learn new techniques in the areas of protein biochemistry, biophysics and structural biology.

Desirable Qualifications

• Experience with membrane protein biochemistry including expression, purification, characterization and functional assays
• Previous exposure to structural biology research including structural analysis and modeling, x-ray crystallography and/or cryo-EM.
• Experience in biophysical methods to characterize protein-protein or protein-ligand interactions (e.g. SPR, DSF, ITC).