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Senior Scientist, Protein Engineering

Flagship Pioneering
September 05, 2026
Full-time
Remote friendly (Cambridge, MA)
Worldwide
Other
Role: Senior Scientist specializing in molecular biology, membrane protein engineering, and surface display technology to develop a novel peptide platform. Responsibilities: design, build, troubleshoot, and optimize membrane protein constructs across diverse architectures; perform plasmid engineering, construct validation, and functional assays; develop high-throughput screening workflows and collaborate with screening and translational teams to ensure construct suitability. Requirements: PhD in molecular biology, bioengineering, or related field; 5+ years industry/postdoctoral experience; extensive hands-on expertise in membrane protein construct design, molecular cloning, and mammalian cell transfection; knowledge of secretory pathway and post-translational modifications; proactive team player with strong organizational and communication skills. Preferred: experience with computational protein design tools (e.g., Rosetta, AlphaFold), flow cytometry, high-throughput screening, and startup experience. High-Value: focus on membrane protein engineering for therapeutic discovery, platform development, early-stage biotech environment, and cross-functional collaboration. Work setup details are not specified.