Senior Scientist, Protein Engineering

Role: Senior Scientist focused on developing a novel platform for small molecule drug discovery within an early-stage biotech startup. Responsibilities include designing and constructing large-scale protein variant libraries, establishing display, selection, and sorting workflows to link genotype to phenotype, and validating library outputs through biochemical and biophysical characterization. The role involves setting technical direction, collaborating closely with computational and screening teams, and translating experimental data into platform insights. Requirements: Ph.D. in molecular biology, biochemistry, or related field with 5+ years of industry or postdoctoral experience; expertise in molecular cloning, protein display systems (e.g., yeast, phage), FACS, and NGS readouts; strong organizational and communication skills. Preferred qualifications include protein expression/purification, bioinformatics, machine learning applications in protein engineering, and startup experience. High-value specifics: early-stage biotech, protein engineering, deep mutational scanning, saturation mutagenesis, platform development, cross-functional collaboration, entrepreneurial environment. Location: not specified; role emphasizes hands-on experimentation and strategic influence.