Senior Scientist, Process Chemistry

Role Summary

Senior Scientist, Process Chemistry at Cambridge, MA. Responsible for multi-step route evaluation and development to establish commercial drug substance manufacturing processes, leading internal and outsourced laboratory activities and developing collaborators.

Responsibilities

• Contribute to the design of novel and efficient synthetic pathways for drug substances undergoing clinical development
• Conduct and oversee route scouting in laboratory to demonstrate synthetic viability
• Use diverse chemistry tools to develop and optimize commercial processes for selected drug substance routes (photochemistry, biocatalysis, flow chemistry, electrochemistry, on-line analysis/PAT, high-throughput experimentation, structural analysis, computational chemistry, etc.)
• Design, plan and execute experimental plans to optimize reaction, purification and isolation operations, ensuring safe, efficient, robust and scalable drug substance manufacturing processes
• Collaborate with analytical chemists, process engineers, pilot plant experts and project managers within the CMC Synthetics organization
• Communicate scientific results clearly via electronic laboratory notebook documentation, development reports, project discussions and presentations
• Provide technical presentations to project teams and management; document work and improvements in eLNB experiments and technical reports
• Establish/extend external network by representing and leading collaborations with academia, industry, or government
• Champion continuous improvements through scientific/technical innovations, workflow optimizations, and digital tool integration

Qualifications

• Ph.D. in organic or synthetic chemistry
• Knowledge in at least one of: advanced analytics, flow chemistry, high throughput experimentation
• Experience in chemocatalysis or biocatalysis including characterization of catalytic processes and/or mechanistic analysis
• Computational capabilities and basic coding skills
• Strong publication record in peer-reviewed journals
• Excellent written and verbal communication skills
• Ability to operate with flexibility in a dynamic environment and under tight deadlines

Preferred Qualifications

• Post-doctoral experience
• Proficiency with Microsoft suite
• Familiarity with digital tools (e.g., SciFinder-n, Reaxys) and advanced data analysis software (e.g., Spotfire)
• Design of experiment, statistical and/or thermo-kinetic modeling
• Strategic and innovative thinker with a track record of developing creative process approaches
• French language skills

Education

• Ph.D. in organic or synthetic chemistry (required)

Additional Requirements

• Location: Cambridge, MA
• No explicit travel details provided