Senior Scientist - PKDM (NAMs-Based Translational ADME Sciences)

Role Summary

Senior Scientist in Amgen’s PKDM organization focusing on NAMs-based translational ADME sciences. Lead design, qualification, and implementation of 3D organoid and microphysiological system platforms to improve translational prediction of drug disposition, target engagement, and pharmacodynamic response. Establish NAMs-based strategies to bridge preclinical and clinical pharmacokinetics and inform candidate prioritization and translational risk assessment.

Responsibilities

• Lead the development and qualification of high-fidelity, human-relevant in vitro models (3D cultures and microphysiological systems) to assess drug disposition, biotransformation, and pharmacodynamic effects.
• Design and execute experimental strategies integrating quantitative endpoints to correlate exposure and response across NAMs and traditional models.
• Advance throughput and data scalability by implementing assay miniaturization, plate-based automation, and high-content imaging workflows.
• Refine parenchymal–stromal co-culture systems and incorporate complementary analytical endpoints to define cellular phenotype and pharmacodynamic response.
• Characterize responses using flow cytometry, multiplexed analytical sampling, confocal microscopy, and live-cell imaging.
• Adopt computational tools and quantitative data pipelines to streamline analysis of complex kinetic and imaging datasets.
• Collaborate across disciplines to define mechanism-based PK liabilities and guide preclinical-to-clinical translation.
• Communicate findings clearly to inform cross-functional teams and drive data-driven decision-making in a fast-paced R&D environment.

Qualifications

• Required: Doctorate in Biomedical Engineering, Pharmacology, Systems Biology, Cellular & Molecular Biology, Biophysics, or related discipline (and relevant post-doc where applicable).
• Required: Or Master’s degree with 3 years of relevant industry experience.
• Required: Or Bachelor’s degree with 5 years of relevant industry experience.
• Preferred: 2+ years of postdoctoral or industry experience applying 3D cellular or microphysiological systems to study drug disposition or disease biology.
• Preferred: Experience in cell model and/or MPS device fabrication, culture, and integration with analytical readouts.
• Preferred: Working understanding of pharmacokinetic principles for small and large molecules and preclinical ADME processes.
• Preferred: Familiarity with bioanalytical and imaging techniques supporting quantitative in vitro pharmacology.
• Preferred: Strong communication, data interpretation, and collaboration skills; ability to synthesize complex data into actionable insights.
• Preferred: Demonstrated ability to innovate and deliver in a dynamic research environment.

Skills

• 3D cell culture and organoid systems
• Microphysiological systems (MPS, organ-on-chip)
• Biotransformation and pharmacokinetics concepts
• Flow cytometry, imaging (confocal, high-content), live-cell imaging
• Analytical readouts and data integration
• Quantitative data analysis and computational tools
• Co-culture techniques and PK/PD interpretation
• Cross-functional collaboration and effective communication

Education

• Doctorate in Biomedical Engineering, Pharmacology, Systems Biology, Cellular & Molecular Biology, Biophysics, or related discipline (or equivalent post-doc experience)
• Alternative: Master’s degree with 3 years of relevant industry experience; or Bachelor’s degree with 5 years of relevant industry experience