Senior Scientist or Principal Scientist, Targeted Proteomics
Kymera Therapeutics
14 hours ago
Remote friendly (Greater Boston)
United States
Clinical Research and Development
How you’ll make an impact:
- Scientific Leadership and Experimental Strategy:
- Partner with cross-functional project teams to define key scientific questions addressable by targeted proteomics.
- Collaborate with stakeholders to prioritize studies based on urgency and program impact.
- Translate program questions into targeted proteomics experiments; execute studies, analyze and interpret data, and communicate findings to cross-functional teams.
- Targeted Proteomics and Assay Development:
- Drive TPD research via development and application of targeted protein mass spectrometry (MS) assays using nano-LC and Orbitrap LC-MS platforms.
- Generate pharmacodynamic (PD) profiles across cells, tissues, and biofluids from human and preclinical species.
- Develop, optimize, qualify, and transfer targeted proteomics assays to support preclinical and clinical studies.
- Innovate and implement targeted proteomics workflows (including automated enrichment) for sensitive, precise, scalable protein quantification.
- External Collaboration and Communication:
- Lead proteomics activities at CRO partners (assay transfer, qualification, execution, data quality oversight).
- Present findings and recommendations to project teams, senior leadership, and external collaborators.
Skills and experience you’ll bring:
- PhD in Biochemistry, Biology, Chemistry, or Chemical Biology with 2+ years targeted, MS-based proteomics industry/startup experience; or BS/MS with 8+ years relevant experience.
- Targeted proteomics expertise, including PRM/MRM stable isotope–labeled peptide assays (DDA/DIA), immunoaffinity enrichment, protein recovery optimization from complex matrices, nanoLC/Orbitrap operation/troubleshooting, and quantitative analysis/reporting using Skyline.
- Cross-functional leadership and strong written/verbal communication.
- Experience preparing reports/supporting documentation for regulatory submissions.
- Experience managing external CRO partnerships for pharmacodynamic data delivery aligned to timelines.
Compensation/Benefits:
- Anticipated base salary range: $115,000 – $215,000; eligibility for annual bonus, equity participation, and comprehensive benefits.
- Scientific Leadership and Experimental Strategy:
- Partner with cross-functional project teams to define key scientific questions addressable by targeted proteomics.
- Collaborate with stakeholders to prioritize studies based on urgency and program impact.
- Translate program questions into targeted proteomics experiments; execute studies, analyze and interpret data, and communicate findings to cross-functional teams.
- Targeted Proteomics and Assay Development:
- Drive TPD research via development and application of targeted protein mass spectrometry (MS) assays using nano-LC and Orbitrap LC-MS platforms.
- Generate pharmacodynamic (PD) profiles across cells, tissues, and biofluids from human and preclinical species.
- Develop, optimize, qualify, and transfer targeted proteomics assays to support preclinical and clinical studies.
- Innovate and implement targeted proteomics workflows (including automated enrichment) for sensitive, precise, scalable protein quantification.
- External Collaboration and Communication:
- Lead proteomics activities at CRO partners (assay transfer, qualification, execution, data quality oversight).
- Present findings and recommendations to project teams, senior leadership, and external collaborators.
Skills and experience you’ll bring:
- PhD in Biochemistry, Biology, Chemistry, or Chemical Biology with 2+ years targeted, MS-based proteomics industry/startup experience; or BS/MS with 8+ years relevant experience.
- Targeted proteomics expertise, including PRM/MRM stable isotope–labeled peptide assays (DDA/DIA), immunoaffinity enrichment, protein recovery optimization from complex matrices, nanoLC/Orbitrap operation/troubleshooting, and quantitative analysis/reporting using Skyline.
- Cross-functional leadership and strong written/verbal communication.
- Experience preparing reports/supporting documentation for regulatory submissions.
- Experience managing external CRO partnerships for pharmacodynamic data delivery aligned to timelines.
Compensation/Benefits:
- Anticipated base salary range: $115,000 – $215,000; eligibility for annual bonus, equity participation, and comprehensive benefits.