Senior Scientist, Multispecific Antibody Engineering (Oncology)

Role Summary

Senior Scientist, Multispecific Antibody Engineering (Oncology) at AbbVie. Discovery Biotherapeutics seeks a highly skilled scientist to design, engineer, and manufacture multispecific biologics to support oncology projects. The role involves engineering, production, and characterization of multispecific biopharmaceutical products, with emphasis on advancing early- and late-stage discovery programs.

Responsibilities

• Responsible for design, engineering and production of multispecific biologics to support oncology
• Evaluate and integrate state-of-the-art technology to improve therapeutic production platforms, and demonstrate creative “out-of-the-box” thinking to solve difficult problems
• Serve as a Multispecifics Engineering representative for cross-functional teams, and contribute scientific insights into multiple projects across various therapeutic areas; recognized expert in multispecifics design and production
• Serve as the Biologics lead on projects to coordinate activities and transitions from hit generation through candidate nomination
• Identify and solve technical problems independently, conceive and implement innovative process research ideas
• Ensure consistency and quality of technical reports
• Provide project update, analysis and advice to cross-functional teams and senior management
• Present original work internally across departments and at internal and external scientific conferences; may author or co-author peer-reviewed scientific papers or patents

Qualifications

• PhD, MS, or BS degree in Biochemistry, Biochemical engineering or related disciplines with typically 0-5 (PhD), 8-11 (MS), or 10-13 (BS) years of experience, ideally in multispecifics biologics engineering
• Extensive experience with protein, biologics, fragments, and multi-specifics design, expression and purification
• Design experience of multispefics for ADC is preferred
• Experience with purification and automation instruments e.g. Akta, Kingfisher, Hamilton
• Sound scientific understanding of current state of protein expression/separation/analytical technologies and ability to explore and develop new approaches for innovative purification
• Experience with CRO coordination
• Experience with in vitro analytical techniques for protein characterization (e.g. SEC, MS, DSF); experience with developability screening for multispecifics preferred
• Strong molecular biology skills (e.g. molecular cloning) and experience with sequence analysis tools (Vector NTI, Geneious, Genedata)
• Knowledge of biologic pipeline progression from exploratory through candidate nomination with program management experience preferred
• Excellent organizational skills and the ability to manage multiple projects simultaneously and adapt to rapid change in priorities
• Candidate must be a goal-oriented team player with excellent verbal and written communication skills, ability to operate in a fast-paced multi-disciplinary environment, and strong can-do attitude
• Recognized in the scientific community through a sustained record of peer-reviewed publications and patents preferred

Skills

• Strong collaboration and relationship-building across functions to enable high performance
• Fast learner with ability to grasp core concepts quickly and adapt direction as needed
• Drive to raise the bar and challenge the status quo
• Fosters a learning environment and openness to experimentation for improvement
• Ability to communicate complex scientific ideas clearly, both verbally and in writing