Senior Scientist, Metabolomics

Role Summary

We are looking for an enthusiastic, curious, and highly motivated individual with experience in metabolomics and bioanalytical LC-MS to join our Translational Profiling group within the Discovery Sciences department in Cambridge, MA. Our Translational Profiling group is a global team of experts in proteomics, metabolomics, lipidomics, super-resolution microscopy, and data science, with locations in Basel, Switzerland, and Cambridge, MA. As a metabolomics/bioanalytical LC/MS expert you will play a key role in advancing our cutting-edge research and drug discovery programs as well as driving the evaluation and implementation of innovative technologies. This role involves collaboration with scientists and project teams across five major disease areas, all dedicated to creating and delivering transformative therapeutics to patients worldwide.

Responsibilities

• In collaboration with project partners, design and execute analytical studies that will address the key scientific question experiments of that drug discovery program.
• Execute all aspects of an analytical study including sample preparation, LC-MS analysis, and data processing and analysis.
• Document your work using our internal documentation system.
• Present the key outcomes of experiments to the project team and plan follow-up steps to further advance the project.
• Develop and implement new LC-MS methods based on project needs.
• Contribute to the assessing and implementing of state-of-the-art analytical methodologies to augment the group‚Äôs technology portfolio and expand its abilities to elucidate the role of metabolism in diseases and the response to therapeutics.

Qualifications

• A new Ph.D. in analytical chemistry, biochemistry, or related field, some postgraduate experience is a plus, or an MS or BS degree with 8+ years‚Äô experience, preferably in pharma/biotech.
• Experience in biological mass spectrometry and metabolomics, including quantitative targeted/multi-targeted LC-MS analyses of endogenous small molecules (metabolites and lipids); metabolic profiling of samples from complex biological matrices.
• Experience in sample preparation and extraction protocols from different cell types, tissues and biofluids of animal or human origin for MS analysis of endogenous small molecules.
• Demonstrated diligence documenting experiments, data and results in electronic lab journal or laboratory information management systems.
• Critical and creative problem-solving skills with independent thinking.
• Good communication and interpersonal skills to work in a collaborative, matrix environment and to build partnerships across functional teams.

Skills

• Analytical chemistry
• Mass spectrometry
• LC-MS method development
• Data processing and analysis
• Project collaboration

Education

• Ph.D. in analytical chemistry, biochemistry, or related field (preferred); or MS/BS with 8+ years of relevant experience