Senior Scientist, Medicinal Chemistry

Role Summary

We are seeking a motivated and innovative individual to join our Medicinal Chemistry team as a Senior Scientist. The successful candidate will play a key role in synthesizing ligands or nucleoside monomers, incorporating them into therapeutic oligonucleotides, and performing bioconjugation of oligonucleotides to ligands targeting cell surface receptors. This position offers a unique opportunity to collaborate with cross-functional teams and contribute directly to the research and development of breakthrough therapies that have the potential to transform patients’ lives.

Responsibilities

• Synthesize ligands or nucleoside monomers and incorporate them into therapeutic oligonucleotides
• Perform bioconjugation of oligonucleotides to ligands targeting cell surface receptors
• Collaborate with cross-functional teams and contribute to the research and development of breakthrough therapies

Qualifications

• Ph.D. in Organic or Nucleic Acid Chemistry with at least 2 years of post-doctoral experience in academia or industry
• Experience in nucleoside/oligonucleotide synthesis and purification
• Experience with purification techniques (e.g., ion exchange, reverse-phase, and size-exclusion chromatography)
• Experience with automated lab equipment (e.g., NMR, LC-MS, etc.)
• A track record of scientific productivity as evidenced by high quality publications and/or patents
• Excellent communication skills and the ability to succeed in a team environment
• An ability to be productive and successful in a fast-paced, interactive, and innovative work environment

Skills

• Nucleoside/oligonucleotide synthesis and purification
• Bioconjugation techniques
• Purification techniques (ion exchange, reverse-phase, size-exclusion)
• Automated instrumentation (NMR, LC-MS)
• Scientific communication and collaboration in cross-functional teams