Senior Scientist, LNP Discovery

Role Summary

Senior Scientist with expertise in lipid nanoparticle (LNP) formulation and application of LNPs to mouse models to join the LNP Discovery team focused on developing non-viral delivery systems for cystic fibrosis therapies. Design and characterization of LNPs for in vivo delivery of Prime Editor RNA molecules, with hands-on in vivo work in pulmonary delivery studies. Opportunity to contribute across the full spectrum of LNP development, from formulation to in vivo delivery, within a collaborative, interdisciplinary cross-functional program team.

Responsibilities

• Design and formulate LNPs using microfluidics; characterize using DLS, zeta potential, pKa, and Ribogreen assays.
• Execute and support in vivo studies focused on pulmonary delivery of LNP formulations including intratracheal delivery in preclinical models.
• Collaborate with internal teams on study design, execution, data collection, and interpretation.
• Support downstream analyses using flow cytometry and molecular biology techniques.
• Collaborate cross-functionally to integrate in vivo findings into delivery platform development.
• Present data in written reports and oral presentations.

Qualifications

• PhD in Biomedical/Chemical Engineering, Biochemistry, or related field with 3+ years of relevant experience (or BS+8, MS+6).
• Experience with lipid nanoparticle (LNP) formulation, QC, and characterization techniques
• Hands-on experience with mouse handling, dosing, and tissue collection; intratracheal delivery strongly preferred.
• Familiarity/experience with molecular biology techniques (e.g., qPCR, DNA sequencing, mammalian cell culture, and flow cytometry preferred).
• Strong organizational and critical thinking skills, attention to detail, and ability to work both independently and as part of a collaborative team.
• Excellent communication and interpersonal skills to thrive in a cross-functional setting.

Skills

• Microfluidic-based LNP formulation
• In vivo pulmonary delivery techniques
• Flow cytometry and molecular biology assay proficiency
• Data analysis, interpretation, and presentation
• Cross-functional collaboration and scientific communication

Education

• PhD in Biomedical/Chemical Engineering, Biochemistry, or related field (required per above) or equivalent combination of education and experience.

Additional Requirements

• Onsite availability in Cambridge, MA (5 days a week).