Senior Scientist - Lipidomics

Role Summary

The Internal Medicine Research Unit (IMRU) at Pfizer seeks a Lipidomics Senior Scientist to advance research in metabolic diseases, ASCVD and CHIP. This role requires application of advanced mass spectrometry to uncover disease biology, and to identify and validate therapeutic targets. Responsibilities include maintaining lab excellence, communicating findings internally and externally, supporting technological and methodological innovation, and collaborating to interpret multi ‘omics data. In addition to drug discovery interests, publication in high-impact journals and presentation of research is encouraged. The candidate will have daily interactions with a team of creative and innovative scientists in a supportive environment for rigorous scientific and drug development training. Strong self-motivation, extensive mass spectrometry experience, excellent communication interpersonal skills, and the ability to work independently and as part of a team are essential.

Responsibilities

• Design and collaboratively execute in vitro and in vivo lipidomics experiments across ASCVD and metabolic indications to drive decision-making, uncover pathogenic disease biology, and identify new therapeutic targets
• Seek out, propose and implement cutting-edge mass spectrometry technology for qualitative and quantitative analysis of endogenous lipids
• Internalize, optimize and implement new sample preparation procedures in step with advancing industry and academic standards
• Advance the integration ion mobility, gas, and liquid chromatography, keeping the lab at the forefront of advances in separation sciences
• Educate and promote the interrogation of lipid biology in the study of Internal Medicine Research Unit (IMRU) priority diseases including ASCVD, obesity, sarcopenia, and Clonal hematopoiesis of indeterminate potential
• Develop and apply LCMS methods to acquire, analyze and interpret lipiodomics data
• Collaborate with computational biologists to integrate lipidomics with other ‚Äòomics data
• Maintain and troubleshoot LCMS instrumentation
• Actively participate in scientific discussions within and outside Pfizer by attending conferences, presenting work, and publishing in high-impact journals

Qualifications

• Must Have
• Ph.D. in Chemistry, Biochemistry, or a related field with 0 to 4 years of applied mass spectrometry metabolomics/lipidomic, OR MS with 7 to 8 years of applied mass spectrometry metabolomics/lipidomic experience
• Deep understanding of fundamentals of separation science including liquid and gas
• Extensive experience operating modern HRAM platforms and associated data analysis package
• Proficiency in LCMS method development and fit-for-purpose validation
• Demonstrated ability to work collaboratively to achieve results in a fast-paced, dynamic environment
• Excellent written and oral communication skills
• Strong problem-solving skills
• Ability to foster a culture that values scientific excellence, urgency, and partnerships with key stakeholders

• Nice to Have
• Experience integrating AI/ML with data processing
• Hands on experience applying Bruker and Thermo MS instrumentation to analyze lipids
• Ion mobility experience
• Stable isotope tracing experience
• Demonstrated mentoring and leadership skills

Physical/Mental Requirements

• Lifting, sitting, bending, standing, walking

Other Job Details

• Relocation support available
• Work Location Assignment: On Premise