Senior Scientist, in vivo Pharmacology, Genetically Engineered Models – Comparative Medicine
Novartis
18 days ago
On-site
Cambridge, MA
Clinical Research and Development
Key Responsibilities:
- Drive the design and generation of genetically engineered mouse models using advanced CRISPR-based genome engineering approaches.
- Develop and implement innovative technologies and approaches for animal genome engineering to advance the platform.
- Lead the genetic and molecular characterization of engineered models to ensure scientific rigor and translational relevance.
- Ensure compliance with institutional and regulatory protocols, policies, and guidelines governing animal research.
- Evaluate emerging technologies and apply new insights to strengthen in vivo disease modeling.
- Collaborate with the global GEMs team and external partners to expand model generation capabilities and meet program priorities.
Essential Requirements:
- Ph.D. in a natural or life science discipline (preferably molecular biology, genetics, or developmental biology) with 2+ years of relevant hands-on experience in a matrixed environment; or MS with 8+ years of directly related experience (preferably in industry).
- Demonstrated expertise in genetically engineered animal model generation, including proficiency in PCR and next-generation sequencing for genetic characterization.
- Strong attention to detail and working knowledge of animal use protocols, welfare compliance requirements, and regulatory standards; experience documenting studies in paper and electronic laboratory records.
Desirable Requirements:
- Proven ability to lead and influence programs or platform initiatives in a highly collaborative, matrixed environment.
- Working knowledge of advanced mouse model characterization (transcriptomics, proteomics, metabolomics).
- Experience managing 1–2 direct reports and supporting talent development and team culture.
- Drive the design and generation of genetically engineered mouse models using advanced CRISPR-based genome engineering approaches.
- Develop and implement innovative technologies and approaches for animal genome engineering to advance the platform.
- Lead the genetic and molecular characterization of engineered models to ensure scientific rigor and translational relevance.
- Ensure compliance with institutional and regulatory protocols, policies, and guidelines governing animal research.
- Evaluate emerging technologies and apply new insights to strengthen in vivo disease modeling.
- Collaborate with the global GEMs team and external partners to expand model generation capabilities and meet program priorities.
Essential Requirements:
- Ph.D. in a natural or life science discipline (preferably molecular biology, genetics, or developmental biology) with 2+ years of relevant hands-on experience in a matrixed environment; or MS with 8+ years of directly related experience (preferably in industry).
- Demonstrated expertise in genetically engineered animal model generation, including proficiency in PCR and next-generation sequencing for genetic characterization.
- Strong attention to detail and working knowledge of animal use protocols, welfare compliance requirements, and regulatory standards; experience documenting studies in paper and electronic laboratory records.
Desirable Requirements:
- Proven ability to lead and influence programs or platform initiatives in a highly collaborative, matrixed environment.
- Working knowledge of advanced mouse model characterization (transcriptomics, proteomics, metabolomics).
- Experience managing 1–2 direct reports and supporting talent development and team culture.