Senior Scientist, in vivo Pharmacology
Stoke Therapeutics
5 hours ago
On-site
Bedford, MA
Clinical Research and Development
Position Purpose:
The Senior Scientist will support preclinical discovery efforts to understand the pharmacokinetics, pharmacodynamics, and efficacy of novel compounds in disease models, including designing and developing robust assays for preclinical pharmacokinetic, pharmacological, and functional biomarkers in tissue samples.
Key Responsibilities:
- Develop and optimize preclinical PK, PD, and biomarker assays to support preclinical research and bridge into early development.
- Apply scientific judgment and creative thinking to adapt and/or create standard methods.
- Collaborate within and across functions to support programs from early discovery through preclinical proof of concept and candidate selection.
- Maintain excellent, timely recordkeeping while adhering to aggressive timelines.
- Author study reports for regulatory filings and scientific manuscripts.
Required Skills & Experience:
- Bachelor’s degree with 16+ years of experience, or Master’s degree with 10+ years post-graduate experience (industry experience required); Pharmacology, Neuroscience, or relevant disciplines preferred.
- Deep experience developing and optimizing assays (e.g., MSD, ELISA, H-ECL, LCMS, qPCR) in complex matrices; IHC skills a plus.
- Drug discovery experience focused on neurology; oligonucleotides experience preferred.
- Experience designing and managing experiments at contract research organizations.
- PK/PD modeling experience a plus.
- Excellent verbal and written communication.
- Strong planning, organization, and time management skills; ability to prioritize multiple projects.
Benefits & Compensation:
- Anticipated salary range: $155,000 - $179,000; final offer based on experience and other factors. Bonus and equity participation.
- Benefits include medical, dental, vision; life and disability insurance; paid parental leave; 401K with company match; unlimited vacation time; tuition assistance; ESPP.
Application Instructions:
- Apply via Stoke’s Career Center: https://www.stoketherapeutics.com/careers/
The Senior Scientist will support preclinical discovery efforts to understand the pharmacokinetics, pharmacodynamics, and efficacy of novel compounds in disease models, including designing and developing robust assays for preclinical pharmacokinetic, pharmacological, and functional biomarkers in tissue samples.
Key Responsibilities:
- Develop and optimize preclinical PK, PD, and biomarker assays to support preclinical research and bridge into early development.
- Apply scientific judgment and creative thinking to adapt and/or create standard methods.
- Collaborate within and across functions to support programs from early discovery through preclinical proof of concept and candidate selection.
- Maintain excellent, timely recordkeeping while adhering to aggressive timelines.
- Author study reports for regulatory filings and scientific manuscripts.
Required Skills & Experience:
- Bachelor’s degree with 16+ years of experience, or Master’s degree with 10+ years post-graduate experience (industry experience required); Pharmacology, Neuroscience, or relevant disciplines preferred.
- Deep experience developing and optimizing assays (e.g., MSD, ELISA, H-ECL, LCMS, qPCR) in complex matrices; IHC skills a plus.
- Drug discovery experience focused on neurology; oligonucleotides experience preferred.
- Experience designing and managing experiments at contract research organizations.
- PK/PD modeling experience a plus.
- Excellent verbal and written communication.
- Strong planning, organization, and time management skills; ability to prioritize multiple projects.
Benefits & Compensation:
- Anticipated salary range: $155,000 - $179,000; final offer based on experience and other factors. Bonus and equity participation.
- Benefits include medical, dental, vision; life and disability insurance; paid parental leave; 401K with company match; unlimited vacation time; tuition assistance; ESPP.
Application Instructions:
- Apply via Stoke’s Career Center: https://www.stoketherapeutics.com/careers/