Senior Scientist – In Vivo Neuroimmunology
Merck
June 24, 2026
On-site
Boston, MA
Clinical Research and Development
Sr. Scientist, In Vivo Neuroimmunology (Neuroimmunology team) — Boston, MA (on-site).
Key responsibilities:
- Design, execute, and report murine in vivo studies for target validation, mechanism of action, PK/PD, and translational biomarkers; own end-to-end study planning and documentation.
- Perform and supervise dosing (IV, IP, PO, SC and other routes), blood collection, cardiac perfusion, and dissection/collection of CNS and peripheral tissues.
- Prepare and fractionate tissues for biochemical/molecular assays; execute immunoassays and RNA analyses (ELISA, OLINK, NULISA, western blot, flow cytometry, qPCR/RT-qPCR, bulk and single-cell RNA sequencing).
- Process, curate, and analyze datasets; use statistical/computational tools to create figures, study reports, and presentations.
- Troubleshoot/optimize workflows, validate new methods, ensure reproducibility, and maintain accurate records.
- Communicate results (reports, presentations, publications) while upholding lab safety, animal welfare, and regulatory compliance.
Work environment:
- On-site lab role; occasional travel (<10%).
Qualifications:
- Master’s (5+ years) or Ph.D. (1+ year) in Neuroscience, Molecular Cell Biology, Pharmacology, Biology, or related field.
Required skills/experience:
- Hands-on rodent in vivo experiments including stereotaxic surgeries (intra-cerebral and intra-cerebroventricular injections).
- Proficiency with dosing routes, blood collection, cardiac perfusion, and CNS/peripheral tissue dissection.
- Experience with tissue fractionation and assays (ELISA, OLINK, NULISA, western blot, RNA sequencing or qPCR).
- Independent data analysis/visualization from multiplexed platforms.
- Strong written/oral communication; ability to work independently in a cross-functional team.
Preferred:
- Industry drug-discovery experience; CSF collection and osmotic-pump management.
- Inflammatory/neurodegenerative transgenic models; PK/PD and dose–response study design.
- Bulk/scRNA-seq/snRNA-seq; Python and/or RStudio; figure/report generation.
- Mentoring/supervising; publications/presentations.
Application:
- Apply via https://jobs.merck.com/us/en (or Workday Jobs Hub). Mention Requisition ID: R403436.
Key responsibilities:
- Design, execute, and report murine in vivo studies for target validation, mechanism of action, PK/PD, and translational biomarkers; own end-to-end study planning and documentation.
- Perform and supervise dosing (IV, IP, PO, SC and other routes), blood collection, cardiac perfusion, and dissection/collection of CNS and peripheral tissues.
- Prepare and fractionate tissues for biochemical/molecular assays; execute immunoassays and RNA analyses (ELISA, OLINK, NULISA, western blot, flow cytometry, qPCR/RT-qPCR, bulk and single-cell RNA sequencing).
- Process, curate, and analyze datasets; use statistical/computational tools to create figures, study reports, and presentations.
- Troubleshoot/optimize workflows, validate new methods, ensure reproducibility, and maintain accurate records.
- Communicate results (reports, presentations, publications) while upholding lab safety, animal welfare, and regulatory compliance.
Work environment:
- On-site lab role; occasional travel (<10%).
Qualifications:
- Master’s (5+ years) or Ph.D. (1+ year) in Neuroscience, Molecular Cell Biology, Pharmacology, Biology, or related field.
Required skills/experience:
- Hands-on rodent in vivo experiments including stereotaxic surgeries (intra-cerebral and intra-cerebroventricular injections).
- Proficiency with dosing routes, blood collection, cardiac perfusion, and CNS/peripheral tissue dissection.
- Experience with tissue fractionation and assays (ELISA, OLINK, NULISA, western blot, RNA sequencing or qPCR).
- Independent data analysis/visualization from multiplexed platforms.
- Strong written/oral communication; ability to work independently in a cross-functional team.
Preferred:
- Industry drug-discovery experience; CSF collection and osmotic-pump management.
- Inflammatory/neurodegenerative transgenic models; PK/PD and dose–response study design.
- Bulk/scRNA-seq/snRNA-seq; Python and/or RStudio; figure/report generation.
- Mentoring/supervising; publications/presentations.
Application:
- Apply via https://jobs.merck.com/us/en (or Workday Jobs Hub). Mention Requisition ID: R403436.