Senior Scientist, In Vitro and In Vivo Pharmacology
Kiniksa Pharmaceuticals
August 26, 2026
On-site
Lexington, MA
Clinical Research and Development
Responsibilities:
- Design, execute, and interpret in vitro pharmacology studies to support target validation, lead characterization, and clinical-stage development.
- Develop mechanistic assays to evaluate target engagement, receptor occupancy, signaling pathways, cytokine modulation, immune cell activation, and pharmacodynamic responses.
- Establish and optimize cell-based and biochemical assays using primary cells, immortalized cell lines, co-culture systems, and in vivo disease-relevant models.
- Generate data packages supporting candidate selection, indication prioritization, dose selection rationale, and clinical biomarker strategies.
- Identify emerging targets and pathways associated with protease-driven and immune-mediated disease.
- Serve as a scientific representative on project teams, contributing to research strategy, development plans, and decision-making.
- Collaborate with external CROs, academic investigators, and clinical collaborators.
- Present findings to senior leadership and project governance teams.
- Author technical reports, study protocols, scientific publications, regulatory support documents, and presentations.
Qualifications and Experience:
- PhD in Pharmacology, Immunology, Cell Biology, Molecular Biology, Biomedical Sciences, or related discipline.
- Typically 5+ years of relevant biotechnology or pharmaceutical industry experience.
- Demonstrated experience supporting discovery and translational development of biologic therapeutics.
- Experience working in cross-functional drug development teams from early research through clinical development.
Standout Skills:
- Strong in vitro and in vivo pharmacology experience.
- Expertise in immunology, inflammation, and biologic drug development.
- Hands-on experience developing/optimizing cell-based and mechanistic assays.
- Ability to analyze complex scientific data and translate into actionable insights.
- Strong collaboration and communication in cross-functional teams.
Pay Range:
- $166,738 - $174,397 USD
- Design, execute, and interpret in vitro pharmacology studies to support target validation, lead characterization, and clinical-stage development.
- Develop mechanistic assays to evaluate target engagement, receptor occupancy, signaling pathways, cytokine modulation, immune cell activation, and pharmacodynamic responses.
- Establish and optimize cell-based and biochemical assays using primary cells, immortalized cell lines, co-culture systems, and in vivo disease-relevant models.
- Generate data packages supporting candidate selection, indication prioritization, dose selection rationale, and clinical biomarker strategies.
- Identify emerging targets and pathways associated with protease-driven and immune-mediated disease.
- Serve as a scientific representative on project teams, contributing to research strategy, development plans, and decision-making.
- Collaborate with external CROs, academic investigators, and clinical collaborators.
- Present findings to senior leadership and project governance teams.
- Author technical reports, study protocols, scientific publications, regulatory support documents, and presentations.
Qualifications and Experience:
- PhD in Pharmacology, Immunology, Cell Biology, Molecular Biology, Biomedical Sciences, or related discipline.
- Typically 5+ years of relevant biotechnology or pharmaceutical industry experience.
- Demonstrated experience supporting discovery and translational development of biologic therapeutics.
- Experience working in cross-functional drug development teams from early research through clinical development.
Standout Skills:
- Strong in vitro and in vivo pharmacology experience.
- Expertise in immunology, inflammation, and biologic drug development.
- Hands-on experience developing/optimizing cell-based and mechanistic assays.
- Ability to analyze complex scientific data and translate into actionable insights.
- Strong collaboration and communication in cross-functional teams.
Pay Range:
- $166,738 - $174,397 USD