Senior Scientist--In Situ Biology

Role Summary

As a member of our ADC Discovery team, you will perform spatial biology experiments to validate targets for antibody-based therapeutics, as well as explore their effects on the tumor microenvironment. You will serve as a histopathology/immunohistochemistry subject matter expert, representing the In Situ Biology sub-team and communicating findings to interdisciplinary project teams.

Responsibilities

• Independently design, execute, and interpret experiments aimed at understanding the spatial context of target expression in tumor and normal tissues.
• Work with project teams, management, pathologists, and peers within the Oncology Research Unit to ensure studies are aligned with project goals and best experimental practices.
• Communicate with project teams to ensure executed studies satisfy intended goals and results are interpreted appropriately.
• Present findings to project teams, leadership, and interdepartmental meetings.
• Represent the In Situ Biology sub-team on project teams as a histopathology/immunohistochemistry subject matter expert and contribute to scientific discussions.
• Evaluate, propose, and implement new procedures in step with advancing industry and academic standards.
• Create reports, contribute to internal and external presentations and journal articles, and diligently record experiments in laboratory notebooks.

Qualifications

• Required: Recent PhD in a biological science related discipline OR MS in a biological science related discipline with 7 years of experience with histopathology techniques OR BS in a biological science related discipline with 9 years of experience with histopathology techniques.
• Required: IHC and ISH assay development expertise.
• Required: Experience with advanced histology methodologies, including multiplex immunohistochemistry and in situ hybridization.
• Required: An understanding of tumor biology.
• Required: Experience working collaboratively in a cross-functional research environment.
• Required: Experience handling multiple projects simultaneously.
• Required: Strong communication skills—verbal, written, and presentation.
• Required: Proficiency using laboratory notebooks and whole slide imaging using digital scanners.
• Required: Proficiency with Microsoft Office software including Excel and PowerPoint, and analysis software like GraphPad Prism or Spotfire.
• Preferred: Experience with digital image analysis tools such as HALO and/or Visiopharm.
• Preferred: Experience with core histology methodologies, such as processing, embedding, and sectioning.
• Preferred: Experience and interest in mentoring and leading colleagues.

Skills

• Histopathology and immunohistochemistry (IHC) / in situ hybridization (ISH)
• Spatial biology and tumor microenvironment analysis
• Data interpretation, presentation, and scientific communication
• Digital imaging and slide analysis
• Cross-functional collaboration

Education

• PhD in biological sciences or related field; or MS with 7 years of histopathology experience; or BS with 9 years of histopathology experience.

Additional Requirements

• Physical/Mental Requirements: Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and complex data analysis.
• Non-standard Work Schedule, Travel Or Environment Requirements: Occasional travel to other Pfizer sites for internal meetings or external conferences.
• Relocation support available.