Senior Scientist, In Silico Discovery

Role: Senior Scientist in In Silico Discovery focused on advancing computational drug design workflows within Johnson & Johnson’s Therapeutics Discovery. Responsibilities include developing and deploying automated structure-based modeling components, such as ligand/protein preparation, docking, and free energy calculations, for early drug discovery projects. The role emphasizes expanding automation, integrating new tools, and supporting co-folding and AI-enhanced workflows in a collaborative, cross-functional environment. Requirements: PhD in computational science or chemistry, strong Python programming, experience with automated workflows and structure-based drug discovery, familiarity with workflow orchestration, and software engineering best practices. Preferred skills include experience with open-source chemoinformatics tools (e.g., RDKit), AI/ML platforms, and advanced methods like free energy calculations or co-folding, with postdoctoral or industry exposure advantageous. HighValue: computational chemistry, automation, structure-based drug design, early-stage discovery, AI integration, co-folding, and cross-disciplinary collaboration. Work setup: primarily based in Belgium, with options in California or Pennsylvania; travel up to 10% domestically and internationally.