Senior Scientist, In Silico Discovery

Role: Senior Scientist in In Silico Discovery within Johnson & Johnson's Therapeutics Discovery, focused on developing and deploying structure-based, physics-driven computational workflows for early drug design. Responsibilities: build and optimize automated protocols for ligand/protein prep, docking, free energy calculations, and co-folding; enhance workflow automation, expand scope, and integrate new tools; collaborate with IT and platform teams to align with enterprise standards; leverage AI to accelerate development. Requirements: PhD in computational science or chemistry; expertise in structure-based drug discovery, programming (preferably Python), and automated workflow development; familiarity with software engineering best practices. Preferred: experience with open-source libraries like RDKit, AI/ML platforms, agentic AI, and advanced methods such as free energy calculations and co-folding; postdoctoral or industry experience in drug discovery advantageous. High-Value: Computational chemistry, automation in early-stage biologics or small molecules, emerging technologies, and cross-functional collaboration in global teams. Work setup: primarily Belgium, with options in California or Pennsylvania; travel up to 10% domestically and internationally.