Senior Scientist, Immunology, In vitro Pharmacology

Role Summary

Senior Scientist, Immunology, In vitro Pharmacology.

Responsibilities

• Lead the functional screening strategy and candidate selection for biologics projects in the gastrointestinal, inflammatory diseases, and fibrosis therapeutic areas.
• Independently designs mechanism of action-relevant functional assays. Develop and validate new functional assays and execute research experimental plan with high scientific rigor.
• Oversees novel scientific projects and manages the workflow of others in a matrixed structure to drive project progress in a timely manner.
• Serves as the functional representative, works with team members from other disciplines, and acts as a senior scientific consultant to provide technical and strategic leadership for research project implementation and coordination.
• Independently finds solutions and develops strategies within area of expertise, uses breadth of knowledge of other disciplines and acts as a scientific resource for BIVP.
• Records experimental design and results in a timely and accurate manner and prepares study reports for internal and regulatory use.
• Scientifically assesses and recommends vendors and outsources nonclinical studies to appropriate contract research organizations.
• Collaborates with automation engineers to identify suitable ways to utilize laboratory automation for the execution of a variety of cell-based assays to enhance throughput and data quality.
• Contributes to multiple projects, interfacing with project teams to meet timelines for project progression.
• Represents the BIVP team to communicate and present research findings clearly and effectively at internal and external meetings.
• Dedicating approximately 30–50% of your time to hands-on bench work to execute and guide experiments underpinning candidate evaluation.

Qualifications

• PhD degree in Immunology, or related scientific discipline with 3+ years of experience, or MS with 9+ years of experience, or BS with 11+ years of experience.
• Industry experience in cell-based assay development and validation.
• Technical knowledge of HTP functional assays and automation experience is a plus.
• Ability to work in a fast-paced environment; self-driven, creative, with a strong team-oriented mentality, positive attitude and effective project management skills.

Skills

• Experienced in the design, development and implementation of in vitro/ex vivo cell-based functional assays to study target-specific drug effects.
• Knowledgeable and experienced in Cell Biology, Immunology and Antibody characterization.
• Experienced with cell-based functional assay platforms including, but not limited to, on-cell binding, reporter assay, AlphaLISA, MSD, flow cytometry, cell adhesion and migration, organ-on-chip and imaging.
• Experienced in troubleshooting, assay optimization and data quality control are a plus.
• Skilled in data analysis, interpretation, and data reporting.
• Experience and knowledge in Inflammatory diseases and/or fibrosis is a plus.

Education

• PhD degree in Immunology, or related scientific discipline with 3+ years of experience, or MS with 9+ years of experience, or BS with 11+ years of experience.