Senior Scientist, Immuno-Oncology, Discovery Biology

Role Summary

We are seeking an innovative and motivated immunologist to advance our portfolio of pioneering T cell engager therapeutics to treat cancers. The successful candidate will join the Discovery Biology Team within the Oncology Thematic Research Center at Bristol Myers Squibb in Seattle, WA. The qualified candidate will provide expertise in immunology and will join a multidisciplinary, groundbreaking team driving projects from discovery through IND. Using their knowledge in T cell immunology, the candidate will have the opportunity to identify and validate novel targets and design novel assay systems to enable next-generation engager cancer therapeutics. This scientist will work in a highly collaborative, dynamic, fast-paced environment involving multiple teams across the company.

Responsibilities

• Identify and validate novel targets for development of T cell engagers.
• Independently design, develop and execute novel in vitro and ex vivo cell-based assays/models to evaluate the efficacy and specificity of T cell engagers.
• Apply knowledge of T cell biology to develop next-generation T cell engagers with improved efficacy and safety profiles.
• Design and implement critical studies required to drive hypothesis-driven research.
• Collaborate across multiple projects / roles in a matrixed environment.
• Present complex concepts to a range of audiences including governance and full team project meetings.
• Utilize excellent communication and interpersonal skills to drive collaboration and alignment with key stakeholders.

Qualifications

• Basic Qualifications:
  • Bachelor's Degree
  • 6+ years of relevant academic and/or industry experience
• Master's Degree
  • 4+ years of relevant academic and/or industry experience
• Ph.D. or equivalent advanced degree in the Life Sciences
  • 2+ years of relevant academic and/or industry experience

Preferred Qualifications

• Ph.D. or equivalent advanced degree in immunology, immuno-oncology, tumor immunology, or a related field
• 2+ years of relevant academic and/or industry experience
• Knowledge of T cell biology and relevant in vitro assay systems and experience with transformed tumor cells is strongly preferred
• Experience with technologies to engineer cell lines and assess immune cell function (e.g., CRISPR, RNAi, Luminex, MSD, IncuCyte-based assays, multi-parameter flow cytometry, T cell activation/proliferation assays, imaging)
• Demonstration of hypothesis-driven, innovative thinking and experimentation
• Self-motivated with project-management thinking; able to work on multiple projects in a matrix environment
• Strong communication skills with peers, supervisors, and governance committees
• Strong problem-solving skills and deep understanding of complex scientific principles
• Excellent documentation and data-compiling abilities for internal and external reports
• Experience with antibody drug discovery and target identification/validation is an advantage