Senior Scientist II, In Vitro Bioassay

Role Summary

Join our bioassay group in developing and executing a variety of in vitro bioassays, including biochemical and cellular assays. Lead scientific research and development to achieve project goals, generate new proposals, and identify and optimize methods and techniques. Act as a lead scientist in your area of expertise and critically evaluate scientific and regulatory advances to integrate knowledge into research and development programs.

Responsibilities

• Develop in vitro assays, screening strategies, mechanistic studies, deliver high quality data from validated screens to drive lead series identification and lead optimization. The successful candidate will develop disease-relevant phenotypic assays using complex cellular models such as primary and stem cells and elucidate mechanism of action of molecules.
• Proficiency with multiple assay formats in higher throughput format
• Engage and collaborate with multiple disease area teams and make substantial contributions to the conception and execution of screens including mechanism of action studies within strict time and quality tolerances.
• Collaborate actively within the group and cross functional team to execute projects and coordinate discovery efforts.
• Maintain cutting-edge awareness of technical developments and scientific knowledge and proactively, applying these when appropriate.
• Effectively communicate results in presentations and written reports and actively participate in cross-functional teams.

Qualifications

• Bachelor’s Degree or equivalent education and typically 12 years of experience, Master’s Degree or equivalent education and typically 10 years of experience, PhD and typically 4 years of experience.
• Demonstrated experience in biochemical and cellular assays, such as protein-ligand binding, enzyme activity and functional cell assays.
• Able to think critically and creatively across multiple disciplines. Demonstrated ability to solve research problems with experience in standard in vitro assays including assay development, optimization, and troubleshooting.
• Able to analyze and critically interpret and report data and research conclusions.
• Ability to multi-task and successfully interact with a diverse team of scientists to deliver results meeting the needs of various stakeholder groups.
• Capable of working independently while contributing and participating in a team environment.
• Excellent oral and written communication skills.

Skills

• Mammalian cell culture
• Cell transfection
• Proficiency with multiple assay formats in higher throughput format