Senior Scientist II, Biophysics and Protein Sciences

Role: Biophysicist specializing in protein characterization to support drug discovery in oncology, focusing on RAS-addicted cancers. Responsibilities: lead the application of orthogonal biophysical techniques (e.g., DSF, SEC-MALS, ITC, SPR) to validate targets, confirm hits, and elucidate protein interactions, especially weak or transient ones relevant to molecular glue platforms. Collaborate closely with Structural Biology, Medicinal Chemistry, and Discovery Biology teams to inform project decisions, develop robust assays, and optimize workflows for protein quality assessment. Requirements: Ph.D. in Biophysics, Biochemistry, Structural Biology, or related field; 8+ years in industry drug discovery; extensive hands-on experience with protein biochemistry and biophysical methods; strong data integration skills across disciplines. Preferred: experience with molecular glues, higher-order biophysics (e.g., SAXS, NMR), and establishing new biophysical workflows; proven track record in mechanistic problem solving and reducing technical risks. HighValue: oncology (RAS-addicted cancers), protein-protein interactions, drug discovery, biophysical assay development, orthogonal validation strategies, regenerative complex characterization. WorkSetup: full-time onsite in Redwood City, CA; salary range $170,000-$212,000.