Senior Scientist I- Translational Medicine- PKS, ADME
Novartis
August 15, 2026
On-site
Cambridge, MA
Clinical Research and Development
Key Responsibilities:
- Plan, execute, and report in-vitro ADME assays (e.g., metabolic stability, permeability) to support PK/discovery strategies.
- Interpret in-vitro ADME data and translate findings to support early discovery, compound optimization, and selection.
- Contribute to novel ADME methodologies and expand assay capabilities.
- Advance lab automation (liquid handling, assay miniaturization, assay multiplexing) to standardize execution and reduce manual effort.
- Execute and/or contribute to fully automated, end-to-end ADME workflows with AI-enabled analytics.
- Develop methods for small/large molecule bio-analysis using LCMS-MS, HRMS, and ICP-MS.
- Troubleshoot lab instrumentation and automation platforms.
- Manage timelines, objectives, and budgets; ensure accurate tracking in company tools; communicate results under supervision.
- Contribute to internal ADME reports and regulatory documents (IND/IMPD/NDA).
- Participate in cross-departmental initiatives; complete required trainings; follow SOP, quality, and HSE guidelines.
Essential Requirements:
- BSc or MSc in relevant field (drug metabolism/pharmacokinetics).
- BSc: 7+ years; MSc: 4+ years ADME/DMPK experience.
- Drug discovery/development or CRO/Pharma/Biotech experience (highly desirable).
- Metabolic stability and permeability assay experience (highly preferable); cell culture a plus.
- Lab automation integrated with AI-enabled analytics (highly desirable).
- Knowledge of related disciplines (bioanalytical, toxicology, biomarker).
- Cross-functional teamwork in a dynamic matrix environment.
- Strong organizational/project skills and critical thinking/problem-solving; fluent English.
Compensation/Benefits (as stated): $89,600–$166,400/year; performance-based cash incentive; potential annual equity awards; comprehensive benefits package and time off.
- Plan, execute, and report in-vitro ADME assays (e.g., metabolic stability, permeability) to support PK/discovery strategies.
- Interpret in-vitro ADME data and translate findings to support early discovery, compound optimization, and selection.
- Contribute to novel ADME methodologies and expand assay capabilities.
- Advance lab automation (liquid handling, assay miniaturization, assay multiplexing) to standardize execution and reduce manual effort.
- Execute and/or contribute to fully automated, end-to-end ADME workflows with AI-enabled analytics.
- Develop methods for small/large molecule bio-analysis using LCMS-MS, HRMS, and ICP-MS.
- Troubleshoot lab instrumentation and automation platforms.
- Manage timelines, objectives, and budgets; ensure accurate tracking in company tools; communicate results under supervision.
- Contribute to internal ADME reports and regulatory documents (IND/IMPD/NDA).
- Participate in cross-departmental initiatives; complete required trainings; follow SOP, quality, and HSE guidelines.
Essential Requirements:
- BSc or MSc in relevant field (drug metabolism/pharmacokinetics).
- BSc: 7+ years; MSc: 4+ years ADME/DMPK experience.
- Drug discovery/development or CRO/Pharma/Biotech experience (highly desirable).
- Metabolic stability and permeability assay experience (highly preferable); cell culture a plus.
- Lab automation integrated with AI-enabled analytics (highly desirable).
- Knowledge of related disciplines (bioanalytical, toxicology, biomarker).
- Cross-functional teamwork in a dynamic matrix environment.
- Strong organizational/project skills and critical thinking/problem-solving; fluent English.
Compensation/Benefits (as stated): $89,600–$166,400/year; performance-based cash incentive; potential annual equity awards; comprehensive benefits package and time off.