Senior Scientist I, siRNA in vitro Biology
AbbVie
June 26, 2026
Remote friendly (Cambridge, MA)
United States
$96,500 - $183,500 USD yearly
Clinical Research and Development
Responsibilities:
- Independently lead in vitro siRNA discovery biology (experimental strategy, assay design, execution, data analysis, interpretation) supporting active therapeutic programs.
- Design, optimize, and validate fit-for-purpose assays to inform siRNA potency, durability, specificity, and mechanism-of-action.
- Drive scientific decision making by integrating siRNA knockdown data with orthogonal readouts (protein, functional, transcriptomic).
- Identify and resolve biological/technical risks related to siRNA activity, delivery, and on-target effects.
- Collaborate with cross-functional partners (chemistry, delivery, bioinformatics, in vivo biology) to advance candidates through discovery milestones.
- Maintain high experimental rigor and productivity with minimal supervision.
- Author internal technical reports; contribute as primary author on publications and/or inventor on patents.
Qualifications:
- BS/MS/PhD in Cell Biology, Molecular Biology, Biochemistry, or related field with typically 10+ years (BS), 8+ years (MS), or 0-3 years (PhD) relevant experience.
- Demonstrated hands-on therapeutic siRNA discovery experience, owning in vitro siRNA studies informing go/no-go, lead selection, or optimization.
- Extensive mammalian cell culture and molecular biology experience (RNA isolation, qPCR, ELISA, Western blot, NGS/Sanger sequencing).
- Ability to independently troubleshoot siRNA-specific challenges (knockdown variability, assay sensitivity limits, off-target interpretation).
- Strong data analysis/critical thinking translating datasets into recommendations.
Desired Qualifications:
- Hands-on stem-loop RT-qPCR experience.
- Experience supporting antibody-based/antibody-enabled delivery strategies.
- Hands-on RNA-seq analysis from siRNA perturbation studies.
- siRNA sequence design/optimization (target site selection, structure–activity relationships).
- Familiarity with CNS-relevant biology/genetic medicine; bioinformatics/scripting (R, Python).
Benefits (if applicable in posting):
- Paid time off (vacation, holidays, sick), medical/dental/vision insurance, 401(k), and eligibility for short-term incentive programs.
How to Apply:
- Submit a resume highlighting direct contributions to siRNA programs.
- Independently lead in vitro siRNA discovery biology (experimental strategy, assay design, execution, data analysis, interpretation) supporting active therapeutic programs.
- Design, optimize, and validate fit-for-purpose assays to inform siRNA potency, durability, specificity, and mechanism-of-action.
- Drive scientific decision making by integrating siRNA knockdown data with orthogonal readouts (protein, functional, transcriptomic).
- Identify and resolve biological/technical risks related to siRNA activity, delivery, and on-target effects.
- Collaborate with cross-functional partners (chemistry, delivery, bioinformatics, in vivo biology) to advance candidates through discovery milestones.
- Maintain high experimental rigor and productivity with minimal supervision.
- Author internal technical reports; contribute as primary author on publications and/or inventor on patents.
Qualifications:
- BS/MS/PhD in Cell Biology, Molecular Biology, Biochemistry, or related field with typically 10+ years (BS), 8+ years (MS), or 0-3 years (PhD) relevant experience.
- Demonstrated hands-on therapeutic siRNA discovery experience, owning in vitro siRNA studies informing go/no-go, lead selection, or optimization.
- Extensive mammalian cell culture and molecular biology experience (RNA isolation, qPCR, ELISA, Western blot, NGS/Sanger sequencing).
- Ability to independently troubleshoot siRNA-specific challenges (knockdown variability, assay sensitivity limits, off-target interpretation).
- Strong data analysis/critical thinking translating datasets into recommendations.
Desired Qualifications:
- Hands-on stem-loop RT-qPCR experience.
- Experience supporting antibody-based/antibody-enabled delivery strategies.
- Hands-on RNA-seq analysis from siRNA perturbation studies.
- siRNA sequence design/optimization (target site selection, structure–activity relationships).
- Familiarity with CNS-relevant biology/genetic medicine; bioinformatics/scripting (R, Python).
Benefits (if applicable in posting):
- Paid time off (vacation, holidays, sick), medical/dental/vision insurance, 401(k), and eligibility for short-term incentive programs.
How to Apply:
- Submit a resume highlighting direct contributions to siRNA programs.