Senior Scientist I, Pipeline Development & Targeted Delivery
AbbVie
2 months ago
On-site
Cambridge, MA
Clinical Research and Development
Senior Scientist I (siRNA), Biotherapeutics and Genetic Medicine (BGM)
Responsibilities:
- Lead research efforts within a cross-functional team to advance new therapeutic targets for siRNA-based pipeline development.
- Design and execute in vitro and in vivo proof-of-concept studies to evaluate novel extrahepatic, targeted siRNA delivery platforms across multiple pipeline programs.
- Design and execute receptor expression profiling, ligand–receptor binding, internalization, and trafficking assays.
- Evaluate functional delivery and target knockdown in receptor-positive cells and tissues.
- Provide scientific leadership and expertise in candidate nomination and pipeline development.
- Work independently and maintain high laboratory productivity with efficiency and scientific rigor.
- Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experiments.
- Collaborate and communicate results with stakeholders and cross-functional teams.
- Contribute as a primary author to scientific publications/presentations and/or primary inventor of patent applications.
- Mentor and support junior scientists.
Qualifications:
- BS, MS, or PhD in chemistry, biology, biochemistry, pharmacology or related field; typically 10+ years (BS), 8+ years (MS), or 0–3 years (PhD).
- Demonstrated expertise in siRNA candidate nomination and pipeline development.
- Demonstrated experience in drug delivery platforms, receptor biology, and targeted delivery.
- Hands-on experience with uptake, trafficking, and functional delivery assays.
- Extensive hands-on molecular and RNA biology experience (cell culture; RNA extraction; RNA quantification: RT-PCR, qPCR, ddPCR; NGS library prep; protein assays: ELISA, Western blot, JESS; flow cytometry; biomarker quantification).
- Experience in assay development and high-throughput screening for siRNA target identification/validation, MoA studies, biodistribution, and biomarker analysis (plus).
- Proven ability to develop, troubleshoot, and refine assays to improve sensitivity, reproducibility, and throughput.
- Highly self-motivated; thrives in a fast-paced, collaborative environment.
- Strong written/verbal communication; experience contributing to technical reports/publications/regulatory documentation.
How to Apply:
- Submit a resume outlining relevant experience and why you are a fit for the position.
Responsibilities:
- Lead research efforts within a cross-functional team to advance new therapeutic targets for siRNA-based pipeline development.
- Design and execute in vitro and in vivo proof-of-concept studies to evaluate novel extrahepatic, targeted siRNA delivery platforms across multiple pipeline programs.
- Design and execute receptor expression profiling, ligand–receptor binding, internalization, and trafficking assays.
- Evaluate functional delivery and target knockdown in receptor-positive cells and tissues.
- Provide scientific leadership and expertise in candidate nomination and pipeline development.
- Work independently and maintain high laboratory productivity with efficiency and scientific rigor.
- Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experiments.
- Collaborate and communicate results with stakeholders and cross-functional teams.
- Contribute as a primary author to scientific publications/presentations and/or primary inventor of patent applications.
- Mentor and support junior scientists.
Qualifications:
- BS, MS, or PhD in chemistry, biology, biochemistry, pharmacology or related field; typically 10+ years (BS), 8+ years (MS), or 0–3 years (PhD).
- Demonstrated expertise in siRNA candidate nomination and pipeline development.
- Demonstrated experience in drug delivery platforms, receptor biology, and targeted delivery.
- Hands-on experience with uptake, trafficking, and functional delivery assays.
- Extensive hands-on molecular and RNA biology experience (cell culture; RNA extraction; RNA quantification: RT-PCR, qPCR, ddPCR; NGS library prep; protein assays: ELISA, Western blot, JESS; flow cytometry; biomarker quantification).
- Experience in assay development and high-throughput screening for siRNA target identification/validation, MoA studies, biodistribution, and biomarker analysis (plus).
- Proven ability to develop, troubleshoot, and refine assays to improve sensitivity, reproducibility, and throughput.
- Highly self-motivated; thrives in a fast-paced, collaborative environment.
- Strong written/verbal communication; experience contributing to technical reports/publications/regulatory documentation.
How to Apply:
- Submit a resume outlining relevant experience and why you are a fit for the position.