Senior Scientist I, Pipeline Development & SAR Optimization
AbbVie
2 months ago
On-site
Cambridge, MA
Clinical Research and Development
Responsibilities:
- Lead research efforts within a cross-functional team to advance new therapeutic targets for siRNA-based pipeline development.
- Design and execute in vitro and in vivo proof-of-concept studies to evaluate siRNA libraries and characterize lead compounds for target engagement and therapeutic benefits.
- Design and execute structure-activity-relationship (SAR) studies for lead optimization, including siRNA sequence, chemical modification patterns, conjugation sites, and linkers.
- Provide scientific leadership and expertise in candidate nomination and pipeline development.
- Work independently and maintain high productivity in the laboratory with efficiency and scientific rigor.
- Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experiments.
- Collaborate and communicate results with stakeholders and cross-functional teams.
- Contribute as a primary author to scientific publications/presentations and/or as a primary inventor of patent applications.
- Mentor and support junior scientists.
Qualifications:
- BS/MS/PhD in chemistry, molecular biology, biochemistry, or related field (10+ years BS; 8+ years MS; 0–3 years PhD).
- Demonstrated expertise in siRNA therapeutics (library design, screening, SAR characterization).
- Demonstrated expertise in siRNA candidate nomination and pipeline development.
- Extensive hands-on molecular/RNA biology experience: cell culture; RNA extraction and quantification (RT-PCR, qPCR, ddPCR); NGS library prep; protein assays (ELISA, Western Blot, JESS); flow cytometry and biomarker quantification.
- Experience in assay development and high-throughput screening for siRNA target ID/validation, MoA studies, biodistribution and biomarker analysis (plus).
- Strong understanding of ex-hepatic delivery of siRNA (highly desirable).
- Proven ability to develop, troubleshoot, and refine assays for sensitivity, reproducibility, and throughput.
- Strong written and verbal communication; experience contributing to technical reports/publications/regulatory documentation.
Benefits (if applicable):
- Paid time off (vacation, holidays, sick); medical/dental/vision insurance; 401(k) to eligible employees.
How to apply:
- Submit your resume outlining relevant experience and why you’re a fit for the position.
- Lead research efforts within a cross-functional team to advance new therapeutic targets for siRNA-based pipeline development.
- Design and execute in vitro and in vivo proof-of-concept studies to evaluate siRNA libraries and characterize lead compounds for target engagement and therapeutic benefits.
- Design and execute structure-activity-relationship (SAR) studies for lead optimization, including siRNA sequence, chemical modification patterns, conjugation sites, and linkers.
- Provide scientific leadership and expertise in candidate nomination and pipeline development.
- Work independently and maintain high productivity in the laboratory with efficiency and scientific rigor.
- Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experiments.
- Collaborate and communicate results with stakeholders and cross-functional teams.
- Contribute as a primary author to scientific publications/presentations and/or as a primary inventor of patent applications.
- Mentor and support junior scientists.
Qualifications:
- BS/MS/PhD in chemistry, molecular biology, biochemistry, or related field (10+ years BS; 8+ years MS; 0–3 years PhD).
- Demonstrated expertise in siRNA therapeutics (library design, screening, SAR characterization).
- Demonstrated expertise in siRNA candidate nomination and pipeline development.
- Extensive hands-on molecular/RNA biology experience: cell culture; RNA extraction and quantification (RT-PCR, qPCR, ddPCR); NGS library prep; protein assays (ELISA, Western Blot, JESS); flow cytometry and biomarker quantification.
- Experience in assay development and high-throughput screening for siRNA target ID/validation, MoA studies, biodistribution and biomarker analysis (plus).
- Strong understanding of ex-hepatic delivery of siRNA (highly desirable).
- Proven ability to develop, troubleshoot, and refine assays for sensitivity, reproducibility, and throughput.
- Strong written and verbal communication; experience contributing to technical reports/publications/regulatory documentation.
Benefits (if applicable):
- Paid time off (vacation, holidays, sick); medical/dental/vision insurance; 401(k) to eligible employees.
How to apply:
- Submit your resume outlining relevant experience and why you’re a fit for the position.