Senior Scientist I, Pipeline Development & SAR Optimization
AbbVie
4 days ago
On-site
Cambridge, MA
$96,500 - $183,500 USD yearly
Clinical Research and Development
Responsibilities:
- Lead research efforts within a cross-functional team to advance new therapeutic targets for siRNA-based pipeline development.
- Design and execute in vitro and in vivo proof-of-concept studies to evaluate siRNA library and characterize lead compounds for target engagement and therapeutic benefits.
- Design and execute structure-activity-relationship (SAR) studies for lead optimization (siRNA sequence, chemical modifications, conjugation sites, linkers).
- Provide scientific leadership for candidate nomination and pipeline development.
- Work independently in the lab with high productivity, efficiency, and scientific rigor.
- Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experiments.
- Collaborate and communicate results with stakeholders and cross-functional teams.
- Contribute as primary author to publications/presentations and/or primary inventor on patent applications.
- Mentor and support junior scientists.
Qualifications:
- BS, MS, or PhD in chemistry, molecular biology, biochemistry, or related field (typically 10+ years BS, 8+ years MS, or 0–3 years PhD).
- Demonstrated expertise in siRNA therapeutics: library design, screening, SAR characterization.
- Demonstrated expertise in siRNA candidate nomination and pipeline development.
- Extensive hands-on molecular/RNA biology experience (cell culture, RNA extraction/quantification: RT-PCR, qPCR, ddPCR; NGS library prep; protein assays: ELISA/Western blot/JESS; flow cytometry/biomarker quantification).
- Assay development and high-throughput screening experience; MoA studies; biodistribution/biomarker analysis (plus).
- Strong understanding of ex-hepatic siRNA delivery (highly desirable).
- Ability to develop, troubleshoot, and refine assays for sensitivity/reproducibility/throughput.
- Strong written/verbal communication; experience contributing to technical reports, publications, or regulatory documentation.
Benefits:
- Comprehensive benefits including paid time off (vacation/holidays/sick), medical/dental/vision insurance, and 401(k) (eligible employees).
- Eligible for short-term incentive programs.
How to Apply:
- Submit a resume outlining relevant experience and why you’re a fit for the position.
- Lead research efforts within a cross-functional team to advance new therapeutic targets for siRNA-based pipeline development.
- Design and execute in vitro and in vivo proof-of-concept studies to evaluate siRNA library and characterize lead compounds for target engagement and therapeutic benefits.
- Design and execute structure-activity-relationship (SAR) studies for lead optimization (siRNA sequence, chemical modifications, conjugation sites, linkers).
- Provide scientific leadership for candidate nomination and pipeline development.
- Work independently in the lab with high productivity, efficiency, and scientific rigor.
- Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experiments.
- Collaborate and communicate results with stakeholders and cross-functional teams.
- Contribute as primary author to publications/presentations and/or primary inventor on patent applications.
- Mentor and support junior scientists.
Qualifications:
- BS, MS, or PhD in chemistry, molecular biology, biochemistry, or related field (typically 10+ years BS, 8+ years MS, or 0–3 years PhD).
- Demonstrated expertise in siRNA therapeutics: library design, screening, SAR characterization.
- Demonstrated expertise in siRNA candidate nomination and pipeline development.
- Extensive hands-on molecular/RNA biology experience (cell culture, RNA extraction/quantification: RT-PCR, qPCR, ddPCR; NGS library prep; protein assays: ELISA/Western blot/JESS; flow cytometry/biomarker quantification).
- Assay development and high-throughput screening experience; MoA studies; biodistribution/biomarker analysis (plus).
- Strong understanding of ex-hepatic siRNA delivery (highly desirable).
- Ability to develop, troubleshoot, and refine assays for sensitivity/reproducibility/throughput.
- Strong written/verbal communication; experience contributing to technical reports, publications, or regulatory documentation.
Benefits:
- Comprehensive benefits including paid time off (vacation/holidays/sick), medical/dental/vision insurance, and 401(k) (eligible employees).
- Eligible for short-term incentive programs.
How to Apply:
- Submit a resume outlining relevant experience and why you’re a fit for the position.